Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GCGR | P47871 | 6/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.35 |
| ▸ | HMGCR | P04035 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | MAPK13 | O15264 | 4/20 | 0.34 |
| ▸ | MAPK12 | P53778 | 4/20 | 0.34 |
| ▸ | MAPK11 | Q15759 | 4/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9791356 | 1.00 | GCGR (0.40) | GCGRADORA2AADORA1ESR1HMGCR | |
| SCHEMBL9524280 | 0.89 | GCGR (0.43) | GCGRADORA2AADORA1PDE3BPDE3A | |
| SCHEMBL9727600 | 0.84 | GCGR (0.41) | GCGRESR1HMGCRCHRM1TBXA2R | |
| SCHEMBL9698874 | 0.84 | GCGR (0.41) | GCGRESR1HMGCRCHRM1TBXA2R | |
| SCHEMBL8949683 | 0.81 | GCGR (0.53) | GCGRESR1HMGCRCHRM1TBXA2R | |
| SCHEMBL9735571 | 0.80 | GCGR (0.39) | GCGRESR1HMGCRCHRM1TBXA2R | |
| SCHEMBL9383069 | 0.80 | GCGR (0.39) | GCGRESR1HMGCRCHRM1TBXA2R | |
| SCHEMBL8949786 | 0.78 | GCGR (0.47) | GCGRESR1HMGCRCHRM1TBXA2R | |
| SCHEMBL9791355 | 0.77 | HMGCR (0.47) | GCGRESR1HMGCRCHRM1TBXA2R | |
| SCHEMBL9380517 | 0.77 | RXRA (0.47) | GCGRESR1HMGCRCHRM1TBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0391185-B1 | Substituted 1,8-naphthyridines | BAYER AG (DE) | 1993-12-29 | — | — | EP | disclosed |
| US-5034399-A | Enzyme inhibitors, anticholesterol agents or antilipemic agents | BAYER AKTIENGESELLSCHAFT (DE) | 1991-07-23 | — | — | US | disclosed |
| EP-0391185-A1 | Substituted 1,8-naphthyridines | BAYER AG (DE) | 1990-10-10 | — | — | EP | disclosed |