Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | MITF | O75030 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.41 |
| ▸ | GBA1 | P04062 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 1/20 | 0.38 |
| ▸ | HTR3A | P46098 | 1/20 | 0.38 |
| ▸ | IDE | P14735 | 1/20 | 0.38 |
| ▸ | UBE2N | P61088 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28192205 | 0.78 | CYP2C19 (0.44) | CYP2C19SIGMAR1SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL27638743 | 0.77 | SIGMAR1 (0.50) | MITFSIGMAR1HRH3SLC6A3SLC6A2 | |
| SCHEMBL28744475 | 0.76 | CYP2C19 (0.43) | CYP2C19SIGMAR1SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL6642409 | 0.74 | MITF (0.48) | MITFSIGMAR1HRH3TDP1SLC6A3 | |
| SCHEMBL28078229 | 0.74 | SIGMAR1 (0.49) | MITFSIGMAR1HRH3GBA1SLC6A3 | |
| SCHEMBL4892854 | 0.73 | GRM2 (0.50) | MITFSIGMAR1GBA1SLC6A3SLC6A2 | |
| SCHEMBL7723235 | 0.71 | CYP2C19 (0.49) | CYP2C19SIGMAR1SLC6A3SLC6A2SLC6A4 | |
| Hydrochloric Acid SCHEMBL27476870 | 0.70 | CYP2C19 (0.48) | CYP2C19SIGMAR1SLC6A3SLC6A2SLC6A4 | |
| SCHEMBL8473445 | 0.69 | TACR1 (0.46) | CYP2C19SLC6A3SLC6A2SLC6A4HTR1A | |
| SCHEMBL6619234 | 0.69 | MITF (0.52) | MITFSIGMAR1TDP1SLC6A3SLC6A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8580821-B2 | Serotonin transporter (SERT) inhibitors for the treatment of depression and anxiety | HOFFMANN-LA ROCHE INC. (US) | 2013-11-12 | — | — | US | disclosed |
| EP-1870396-B1 | BENZYLOXYPROPYLAMINE DERIVATIVE | NIPPON ZOKI PHARMACEUTICAL CO (JP) | 2012-10-31 | — | — | EP | disclosed |
| EP-2004605-B1 | PIPERIDINE DERIVATIVES USEFUL AS SEROTONIN TRANSPORTER INHIBITORS AND NEUROKININ-1 RECEPTOR ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2011-06-29 | — | — | EP | disclosed |
| US-7939552-B2 | Tachykinin receptor anatgonist; good transfer into blood; long half-life; stability; bradycardial agents; antiinflammatory agents ; antallergens; analgesics; antiemetics; irritable bowel disorders; skin disorders; antidepressants; antiischemic agents ; anxiolytic agents; autoimmune diseases; muscle relax | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 2011-05-10 | — | — | US | disclosed |
| US-20110105561-A1 | SEROTONIN TRANSPORTER (SERT) INHIBITORS FOR THE TREATMENT OF DEPRESSION AND ANXIETY | GRUNDSCHOBER CHRISTOPHE | 2011-05-05 | — | — | US | disclosed |
| US-7872022-B2 | Serotonin transporter (SERT) inhibitors for the treatment of depression and anxiety | HOFFMANN-LA ROCHE INC. (US) | 2011-01-18 | — | — | US | disclosed |
| EP-1957450-B1 | SEROTONIN TRANSPORTER (SERT) INHIBITORS | HOFFMANN LA ROCHE (CH) | 2009-06-24 | — | — | EP | disclosed |
| EP-2004605-A1 | PIPERIDINE DERIVATIVES USEFUL AS SEROTONIN TRANSPORTER INHIBITORS AND NEUROKININ-1 RECEPTOR ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2008-12-24 | — | — | EP | disclosed |
| US-20080262230-A1 | Benzyloxypropylamine Derivative | NIPPON ZOKI PHARMACEUTICAL CO., LTD. (JP) | 2008-10-23 | — | — | US | disclosed |
| EP-1957450-A1 | SEROTONIN TRANSPORTER (SERT) INHIBITORS | F.HOFFMANN-LA ROCHE AG (CH) | 2008-08-20 | — | — | EP | disclosed |
| EP-1870396-A1 | BENZYLOXYPROPYLAMINE DERIVATIVE | Nippon Zoki Pharmaceutical Co. Ltd. (JP) | 2007-12-26 | — | — | EP | disclosed |
| WO-2007113153-A1 | PIPERIDINE DERIVATIVES USEFUL AS SEROTONIN TRANSPORTER INHIBITORS AND NEUROKININ-1 RECEPTOR ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-10-11 | — | — | WO | disclosed |
| US-20070232652-A1 | Serotonin transporter (sert) inhibitors for the treatment of depression and anxiety | HOFFMAN-LA ROCHE INC. | 2007-10-04 | — | — | US | disclosed |
| WO-2007063009-A1 | SEROTONIN TRANSPORTER (SERT) INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-07 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110105561-A1 | SEROTONIN TRANSPORTER (SERT) INHIBITORS FOR THE TREATMENT OF DEPRESSION AND ANXIETY | SLC6A4, SLC6A1, SLC1A2 | CYP2C19 409/4885MITF 2240/4885SIGMAR1 226/4885 |
| US-20070232652-A1 | Serotonin transporter (sert) inhibitors for the treatment of depression and anxiety | SLC6A4, SLC6A1, SLC1A2 | CYP2C19 409/4885MITF 2240/4885SIGMAR1 226/4885 |
| US-20080262230-A1 | Benzyloxypropylamine Derivative | BDKRB2, BDKRB1, PNMT | CYP2C19 916/4885MITF 3068/4885SIGMAR1 657/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.