Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PHGDH | O43175 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.54 |
| ▸ | IDO1 | P14902 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | LMNA | P02545 | 3/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.44 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.44 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.44 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.44 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10359712 | 0.88 | MAPK1 (0.53) | MAPTL3MBTL1ALDH1A1MAPK1CASP7 | |
| SCHEMBL23536025 | 0.81 | ALDH1A1 (0.62) | MAPTL3MBTL1ALDH1A1LMNAMAPK1 | |
| SCHEMBL29931868 | 0.81 | ALDH1A1 (0.62) | MAPTL3MBTL1ALDH1A1LMNAMAPK1 | |
| SCHEMBL677655 | 0.77 | MAPK1 (0.55) | MAPTL3MBTL1ALDH1A1MAPK1CASP7 | |
| SCHEMBL28867395 | 0.76 | GAA (0.43) | MAPTL3MBTL1ALDH1A1LMNAMAPK1 | |
| SCHEMBL27306411 | 0.76 | MAPK1 (0.50) | PHGDHMAPTL3MBTL1ALDH1A1MAPK1 | |
| SCHEMBL247794 | 0.73 | L3MBTL1 (0.74) | PHGDHMAPTL3MBTL1IDO1ALDH1A1 | |
| SCHEMBL24187914 | 0.72 | PDK1 (0.55) | PHGDHMAPTL3MBTL1ALDH1A1MAPK1 | |
| SCHEMBL14247904 | 0.71 | MAPK1 (0.46) | MAPTL3MBTL1ALDH1A1LMNAMAPK1 | |
| SCHEMBL10868680 | 0.71 | MEN1 (0.49) | MAPTL3MBTL1ALDH1A1MAPK1CASP7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120058085-A1 | Deuterium Modified Benzimidazoles | CONCERT PHARMACEUTICALS, INC. | 2012-03-08 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120058085-A1 | Deuterium Modified Benzimidazoles | POLRMT, EIF2AK2, DUT | PHGDH 673/4885MAPT 4232/4885L3MBTL1 2089/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.