Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | TYK2 | P29597 | 2/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.49 |
| ▸ | MEN1 | O00255 | 5/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.44 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | RAF1 | P04049 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9524233 | 0.89 | DHODH (0.54) | MAPTKMT2AMEN1ALDH1A1DHODH | |
| SCHEMBL9525813 | 0.87 | MEN1 (0.50) | MAPTKMT2AMEN1DHODHNPC1 | |
| SCHEMBL9525671 | 0.86 | RAB9A (0.57) | MAPTKMT2AMEN1ALDH1A1NPC1 | |
| SCHEMBL9524693 | 0.82 | FADS1 (0.58) | MAPTKMT2AMEN1ALDH1A1NPC1 | |
| SCHEMBL9524171 | 0.82 | MAPT (0.49) | MAPTKMT2AMEN1ALDH1A1NPC1 | |
| SCHEMBL9523781 | 0.81 | KCNMA1 (0.54) | MAPTTYK2JAK2KMT2AMEN1 | |
| SCHEMBL9524202 | 0.81 | F2 (0.56) | MAPTKMT2AMEN1ALDH1A1NPC1 | |
| SCHEMBL9527461 | 0.79 | ADORA3 (0.61) | MAPTKMT2AMEN1ALDH1A1NPC1 | |
| SCHEMBL9523892 | 0.78 | HIF1A (0.53) | MAPTTYK2JAK2NPC1RAB9A | |
| SCHEMBL9524714 | 0.77 | NPC1 (0.56) | MAPTKMT2AMEN1ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0277791-B1 | CINNOLINE-CARBOXAMIDES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1993-06-02 | — | — | EP | disclosed |
| US-4826837-A | IMMUNOMODULATORS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-05-02 | — | — | US | disclosed |
| EP-0277791-A2 | Cinnoline-carboxamides and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-08-10 | — | — | EP | disclosed |