Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | GLA | P06280 | 2/20 | 0.35 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | CASP1 | P29466 | 2/20 | 0.35 |
| ▸ | CASP7 | P55210 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8796181 | 0.83 | GRM4 (0.35) | MAPTSMN1; SMN2NPC1RAB9AHSD17B10 | |
| SCHEMBL9524854 | 0.83 | RARA (0.48) | KDM4ERARARARBRARGKDM6B | |
| SCHEMBL8794576 | 0.81 | CBFB (0.43) | — | |
| SCHEMBL9525024 | 0.81 | RARA (0.41) | KMT2ASMN1; SMN2NPC1PKMRAB9A | |
| SCHEMBL9525543 | 0.80 | TGFBR1 (0.41) | MAPTKMT2ASMN1; SMN2NPC1PKM | |
| SCHEMBL9527612 | 0.78 | NPC1 (0.44) | MAPTKMT2ASMN1; SMN2TP53NPC1 | |
| SCHEMBL9524965 | 0.77 | ADRA1A (0.39) | MAPTSMN1; SMN2TP53NPC1PKM | |
| SCHEMBL9525700 | 0.76 | KDM4E (0.39) | MAPTSMN1; SMN2TP53NPC1PKM | |
| SCHEMBL9087775 | 0.76 | ALDH1A1 (0.34) | MAPTSMN1; SMN2HTTKDM4EALDH1A1 | |
| SCHEMBL9086316 | 0.76 | MAPT (0.46) | MAPTKMT2ANPC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0298452-B1 | 2H-1-BENZOPYRANE DERIVATIVES SUBSTITUTED IN POSITION 4 BY ARYL OR N-HETEROARYL | F. HOFFMANN-LA ROCHE AG (CH) | 1993-06-30 | — | — | EP | disclosed |
| EP-0298452-A2 | 2H-1-benzopyrane derivatives substituted in position 4 by aryl or N-heteroaryl | F. HOFFMANN-LA ROCHE AG (CH) | 1989-01-11 | — | — | EP | disclosed |