Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | GPR52 | Q9Y2T5 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.36 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.36 |
| ▸ | CES2 | O00748 | 1/20 | 0.36 |
| ▸ | CES1 | P23141 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | APEX1 | P27695 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9525605 | 1.00 | SIGMAR1 (0.44) | SIGMAR1SMN1; SMN2GPR52ALDH1A1MAPT | |
| SCHEMBL4535241 | 0.80 | SIGMAR1 (0.47) | SIGMAR1PTPN1 | |
| SCHEMBL9528603 | 0.71 | CYP19A1 (0.50) | ALDH1A1KMT2AMEN1 | |
| SCHEMBL7551804 | 0.71 | SMN1; SMN2 (0.49) | SMN1; SMN2GPR52ALDH1A1MAPTKMT2A | |
| SCHEMBL9528596 | 0.71 | CYP19A1 (0.50) | ALDH1A1KMT2AMEN1 | |
| SCHEMBL8671036 | 0.70 | TDP1 (0.45) | SIGMAR1GPR52ALDH1A1PTPN1CES2 | |
| SCHEMBL8671035 | 0.70 | TDP1 (0.45) | SIGMAR1GPR52ALDH1A1PTPN1CES2 | |
| SCHEMBL9857762 | 0.70 | ALDH1A1 (0.45) | SMN1; SMN2ALDH1A1MAPTKMT2APTGS1 | |
| SCHEMBL9857756 | 0.70 | ALDH1A1 (0.45) | SMN1; SMN2ALDH1A1MAPTKMT2APTGS1 | |
| SCHEMBL8511316 | 0.70 | SIGMAR1 (0.53) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0231996-B1 | NOVEL AMINO ACID DERIVATIVES | NOVO NORDISK A/S (DK) | 1993-10-06 | — | — | EP | disclosed |
| US-4931450-A | Amino acid derivatives | NOVO INDUSTRI A/S (DK) | 1990-06-05 | — | — | US | disclosed |
| EP-0231996-A2 | Novel amino acid derivatives | NOVO NORDISK A/S (DK) | 1987-08-12 | — | — | EP | disclosed |