Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 4/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | XDH | P47989 | 2/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | GFER | P55789 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | FUT7 | Q11130 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5981948 | 0.77 | MAPT (0.37) | MAPTKMT2AHSD17B10TSHRLMNA | |
| SCHEMBL9529269 | 0.76 | TSHR (0.45) | GSK3BMAPTKMT2AHSD17B10TSHR | |
| SCHEMBL7670938 | 0.76 | TSHR (0.45) | GSK3BMAPTKMT2AHSD17B10TSHR | |
| SCHEMBL577650 | 0.76 | MAPT (0.45) | MAPTKMT2AHSD17B10TSHRLMNA | |
| SCHEMBL577651 | 0.74 | MAPT (0.44) | MAPTKMT2AHSD17B10TSHRLMNA | |
| SCHEMBL1374020 | 0.74 | TSHR (0.44) | GSK3BMAPTKMT2AHSD17B10TSHR | |
| SCHEMBL11522285 | 0.74 | MAPT (0.49) | GSK3BMAPTKMT2AHSD17B10TSHR | |
| SCHEMBL3686211 | 0.71 | RAF1 (0.51) | MAPTKMT2AHSD17B10TSHRLMNA | |
| SCHEMBL12018902 | 0.71 | ALDH1A1 (0.44) | GSK3BMAPTKMT2AHSD17B10TSHR | |
| SCHEMBL8033005 | 0.70 | LMNA (0.41) | GSK3BMAPTKMT2AHSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0297697-B1 | Thiophene-2-carboxamide derivatives and their pharmaceutical use | LILLY SA (ES) | 1993-12-29 | — | — | EP | disclosed |
| EP-0297697-A1 | Thiophene-2-carboxamide derivatives and their pharmaceutical use | LILLY S.A. (ES) | 1989-01-04 | — | — | EP | disclosed |