Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FAAH | O00519 | 4/20 | 0.48 |
| ▸ | GHSR | Q92847 | 1/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 4/20 | 0.45 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.43 |
| ▸ | ANPEP | P15144 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5827457 | 0.87 | FAAH (0.41) | FAAHGHSRMTNR1AMTNR1BP2RX7 | |
| SCHEMBL8588823 | 0.83 | MTNR1A (0.56) | FAAHGHSRMTNR1AMTNR1BP2RX7 | |
| SCHEMBL6534265 | 0.81 | GHSR (0.49) | FAAHGHSRMTNR1AMTNR1BP2RX7 | |
| SCHEMBL11790481 | 0.80 | MTNR1A (0.54) | FAAHGHSRMTNR1AMTNR1BP2RX7 | |
| SCHEMBL6534185 | 0.78 | FAAH (0.53) | FAAHGHSRMTNR1AMTNR1BP2RX7 | |
| SCHEMBL6427539 | 0.78 | FAAH (0.53) | FAAHGHSRMTNR1AMTNR1BP2RX7 | |
| SCHEMBL5608206 | 0.78 | FAAH (0.53) | FAAHGHSRMTNR1AMTNR1BP2RX7 | |
| SCHEMBL367535 | 0.78 | FAAH (0.53) | FAAHGHSRMTNR1AMTNR1BP2RX7 | |
| SCHEMBL1193346 | 0.78 | FAAH (0.53) | FAAHGHSRMTNR1AMTNR1BP2RX7 | |
| SCHEMBL3195898 | 0.78 | GHSR (0.49) | FAAHGHSRMTNR1AMTNR1BP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0310745-B1 | SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR PREPARATION AND USE | ORION-YHTYMÄ OY (FI) | 1993-01-27 | — | — | EP | disclosed |
| EP-0183492-B1 | SUBSTITUTED IMIDAZOLE DERIVATIVES AND THEIR PREPARATION AND USE | Farmos-Yhtyma Oy (FI) | 1989-11-15 | — | — | EP | disclosed |
| EP-0310745-A2 | Substituted imidazole derivatives and their preparation and use | ORION-YHTYMÄ OY (FI) | 1989-04-12 | — | — | EP | disclosed |
| US-4689339-A | 4-dihydroinden-2-yl-, 4-tetrahydronaphth-2-yl-, and 4-dihydrobenzofuran-2-ylimidazoles, useful to block α2 -adrenergic receptors | FARMOS YHTYMA OY (FI) | 1987-08-25 | — | — | US | disclosed |
| EP-0183492-A1 | Substituted imidazole derivatives and their preparation and use | Farmos-Yhtyma Oy (FI) | 1986-06-04 | — | — | EP | disclosed |