Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR7 | P34969 | 4/20 | 0.49 |
| ▸ | DRD2 | P14416 | 7/20 | 0.48 |
| ▸ | DRD3 | P35462 | 7/20 | 0.48 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | DRD5 | P21918 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9526832 | 0.90 | HTR7 (0.47) | HTR7DRD2DRD3ADRA1AALDH1A1 | |
| SCHEMBL9527290 | 0.88 | KCNH2 (0.51) | DRD2 | |
| SCHEMBL9527623 | 0.87 | HTR7 (0.49) | HTR7DRD2DRD3ADRA1AALDH1A1 | |
| SCHEMBL9531700 | 0.86 | BPTF (0.46) | DRD2ADRA1A | |
| SCHEMBL9527024 | 0.85 | BPTF (0.53) | HTR7DRD2DRD3ADRA1ASIGMAR1 | |
| SCHEMBL9531418 | 0.85 | KCNH2 (0.53) | HTR7DRD2DRD3ADRA1AALDH1A1 | |
| SCHEMBL9527102 | 0.84 | DRD2 (0.50) | HTR7DRD2DRD3ADRA1ASIGMAR1 | |
| SCHEMBL9529009 | 0.82 | BPTF (0.54) | DRD2ADRA1A | |
| SCHEMBL9527138 | 0.82 | ATM (0.54) | HTR7DRD2DRD3ADRA1AALDH1A1 | |
| SCHEMBL9529694 | 0.81 | DRD2 (0.54) | DRD2DRD3ADRA1ASIGMAR1DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372305-B1 | PIPERAZINYLALKYL-3(2H)-PYRIDAZINONES, METHOD FOR THEIR PREPARATION AND THEIR USE AS ANTIHYPERTENSIVE AGENTS | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1993-08-04 | — | — | EP | disclosed |
| EP-0372305-A1 | Piperazinylalkyl-3(2H)-pyridazinones, method for their preparation and their use as antihypertensive agents | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1990-06-13 | — | — | EP | disclosed |