Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.54 |
| ▸ | HTR2A | P28223 | 2/20 | 0.54 |
| ▸ | HRH1 | P35367 | 1/20 | 0.54 |
| ▸ | BPTF | Q12830 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.43 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.43 |
| ▸ | HTR1A | P08908 | 3/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.41 |
| ▸ | DRD5 | P21918 | 1/20 | 0.41 |
| ▸ | DRD3 | P35462 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9527024 | 0.89 | BPTF (0.53) | DRD2HTR2AHRH1BPTFHTR1A | |
| SCHEMBL9527274 | 0.85 | BPTF (0.47) | BPTFHTR1AMAPTLMNA | |
| SCHEMBL9529009 | 0.85 | BPTF (0.54) | DRD2HTR2AHRH1BPTFKAT2B | |
| SCHEMBL9528853 | 0.85 | KAT2B (0.60) | DRD2HTR2AHRH1BPTFTP53 | |
| SCHEMBL9527290 | 0.84 | KCNH2 (0.51) | DRD2HRH1BPTFDRD4MAPT | |
| SCHEMBL9531700 | 0.84 | BPTF (0.46) | DRD2HTR2AHRH1BPTFTP53 | |
| SCHEMBL9528184 | 0.83 | ADRA1A (0.58) | DRD2HTR2AHRH1BPTFTP53 | |
| SCHEMBL27263072 | 0.81 | BPTF (0.46) | DRD2HTR2AHRH1BPTFTP53 | |
| SCHEMBL9526907 | 0.81 | HTR7 (0.49) | DRD2ADRA1ADRD5DRD3SIGMAR1 | |
| SCHEMBL9531418 | 0.81 | KCNH2 (0.53) | DRD2HTR2AHRH1HTR1AADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372305-B1 | PIPERAZINYLALKYL-3(2H)-PYRIDAZINONES, METHOD FOR THEIR PREPARATION AND THEIR USE AS ANTIHYPERTENSIVE AGENTS | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1993-08-04 | — | — | EP | disclosed |
| US-5034391-A | Piperazinylalkyl-3(2H)-pyridazinones and the use thereof as agents lowering blood pressure | CL PHARMA AKTIENGESELLSCHAFT (AT) | 1991-07-23 | — | — | US | disclosed |
| EP-0372305-A1 | Piperazinylalkyl-3(2H)-pyridazinones, method for their preparation and their use as antihypertensive agents | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1990-06-13 | — | — | EP | disclosed |