Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BPTF | Q12830 | 1/20 | 0.54 |
| ▸ | ADRA1D | P25100 | 8/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 8/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 8/20 | 0.43 |
| ▸ | HTR1A | P08908 | 7/20 | 0.43 |
| ▸ | HRH1 | P35367 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | HTR2A | P28223 | 1/20 | 0.37 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9527290 | 0.89 | KCNH2 (0.51) | BPTFHRH1MAPK1DRD2DRD4 | |
| SCHEMBL9527024 | 0.87 | BPTF (0.53) | BPTFADRA1DADRA1AADRA1BHTR1A | |
| SCHEMBL9529694 | 0.85 | DRD2 (0.54) | BPTFADRA1DADRA1AADRA1BHTR1A | |
| SCHEMBL9527132 | 0.84 | KAT2B (0.49) | BPTFKAT2B | |
| SCHEMBL9531418 | 0.83 | KCNH2 (0.53) | ADRA1AADRA1BHTR1AHRH1DRD2 | |
| SCHEMBL9531700 | 0.82 | BPTF (0.46) | BPTFADRA1DADRA1AADRA1BHTR1A | |
| SCHEMBL9527274 | 0.82 | BPTF (0.47) | BPTFHTR1AMAPK1 | |
| SCHEMBL9526907 | 0.82 | HTR7 (0.49) | ADRA1ADRD2 | |
| SCHEMBL9527111 | 0.81 | BPTF (0.51) | BPTFADRA1DADRA1AADRA1BHTR1A | |
| SCHEMBL9531556 | 0.80 | ADRA1A (0.53) | BPTFADRA1DADRA1AADRA1BHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372305-B1 | PIPERAZINYLALKYL-3(2H)-PYRIDAZINONES, METHOD FOR THEIR PREPARATION AND THEIR USE AS ANTIHYPERTENSIVE AGENTS | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1993-08-04 | — | — | EP | disclosed |
| EP-0358290-B1 | 2-Oxa-bicyclo[2.2.1]heptane derivatives and medicines containing these compounds | SCHERING AKTIENGESELLSCHAFT (DE) | 1993-02-03 | — | — | EP | disclosed |
| US-5034391-A | Piperazinylalkyl-3(2H)-pyridazinones and the use thereof as agents lowering blood pressure | CL PHARMA AKTIENGESELLSCHAFT (AT) | 1991-07-23 | — | — | US | disclosed |
| EP-0372305-A1 | Piperazinylalkyl-3(2H)-pyridazinones, method for their preparation and their use as antihypertensive agents | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1990-06-13 | — | — | EP | disclosed |
| EP-0358290-A1 | 2-Oxa-bicyclo[2.2.1]heptane derivatives and medicines containing these compounds | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-03-14 | — | — | EP | disclosed |