Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | BPTF | Q12830 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | HRH1 | P35367 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9527024 | 0.90 | BPTF (0.53) | BPTFHRH1KMT2ADRD2 | |
| SCHEMBL9531418 | 0.90 | KCNH2 (0.53) | KCNH2MAPTHRH1DRD2DRD4 | |
| SCHEMBL9529009 | 0.89 | BPTF (0.54) | MAPK1BPTFHRH1DRD2DRD4 | |
| SCHEMBL9526907 | 0.88 | HTR7 (0.49) | DRD2 | |
| SCHEMBL9527765 | 0.85 | KMT2A (0.53) | KCNH2BPTFMAPTHRH1KMT2A | |
| SCHEMBL9527111 | 0.84 | BPTF (0.51) | BPTFHRH1 | |
| SCHEMBL9529694 | 0.84 | DRD2 (0.54) | BPTFMAPTHRH1DRD2DRD4 | |
| SCHEMBL9531700 | 0.83 | BPTF (0.46) | BPTFMAPTHRH1KMT2ADRD2 | |
| SCHEMBL9531556 | 0.81 | ADRA1A (0.53) | BPTFDRD2 | |
| SCHEMBL9527274 | 0.81 | BPTF (0.47) | MAPK1BPTFMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372305-B1 | PIPERAZINYLALKYL-3(2H)-PYRIDAZINONES, METHOD FOR THEIR PREPARATION AND THEIR USE AS ANTIHYPERTENSIVE AGENTS | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1993-08-04 | — | — | EP | disclosed |
| US-5034391-A | Piperazinylalkyl-3(2H)-pyridazinones and the use thereof as agents lowering blood pressure | CL PHARMA AKTIENGESELLSCHAFT (AT) | 1991-07-23 | — | — | US | disclosed |
| EP-0372305-A1 | Piperazinylalkyl-3(2H)-pyridazinones, method for their preparation and their use as antihypertensive agents | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1990-06-13 | — | — | EP | disclosed |