Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PYGL | P06737 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | NOS3 | P29474 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | MAT2A | P31153 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.34 |
| ▸ | CHKA | P35790 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9527710 | 0.87 | KMT2A (0.37) | LMNASMN1; SMN2KMT2APOLBMEN1 | |
| SCHEMBL9524747 | 0.86 | ALDH1A1 (0.37) | LMNASMN1; SMN2POLBTDP1MAPT | |
| SCHEMBL9527463 | 0.86 | LCK (0.38) | KMT2APOLBCYP2C19MEN1CYP2D6 | |
| SCHEMBL9524768 | 0.84 | TRPM8 (0.40) | LMNASMN1; SMN2KMT2APOLBCYP1A2 | |
| SCHEMBL9524841 | 0.78 | TRPM8 (0.40) | PYGLLMNASMN1; SMN2KMT2ACYP2C19 | |
| SCHEMBL9525753 | 0.74 | KCNMA1 (0.57) | LMNASMN1; SMN2KMT2AMEN1TSHR | |
| SCHEMBL9523543 | 0.73 | MEN1 (0.44) | LMNASMN1; SMN2KMT2APOLBCYP1A2 | |
| SCHEMBL10915918 | 0.72 | ALDH1A1 (0.44) | LMNASMN1; SMN2POLBCYP2C9TDP1 | |
| SCHEMBL9524344 | 0.69 | TMPRSS4 (0.51) | KMT2APOLBMEN1 | |
| SCHEMBL9524492 | 0.68 | KCNMA1 (0.46) | LMNASMN1; SMN2KMT2APOLBCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0277791-B1 | CINNOLINE-CARBOXAMIDES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1993-06-02 | — | — | EP | disclosed |
| US-4826837-A | IMMUNOMODULATORS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-05-02 | — | — | US | disclosed |
| EP-0277791-A2 | Cinnoline-carboxamides and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-08-10 | — | — | EP | disclosed |