Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | BLM | P54132 | 1/20 | 0.37 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | CSF1R | P07333 | 2/20 | 0.37 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10643357 | 0.95 | POLB (0.39) | TRPM8POLBLMNAKDM4ETHRB | |
| SCHEMBL9527710 | 0.85 | KMT2A (0.37) | POLBLMNAKDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL9524747 | 0.84 | ALDH1A1 (0.37) | POLBLMNAKDM4ERAB9ASMN1; SMN2 | |
| SCHEMBL9527340 | 0.84 | PYGL (0.40) | POLBLMNATHRBCYP1A2SMN1; SMN2 | |
| SCHEMBL9527463 | 0.84 | LCK (0.38) | POLBNPSR1RAB9AMEN1KMT2A | |
| SCHEMBL9524202 | 0.77 | F2 (0.56) | LMNANPSR1RAB9ASMN1; SMN2MEN1 | |
| SCHEMBL9524841 | 0.72 | TRPM8 (0.40) | TRPM8LMNAKDM4ESMN1; SMN2MEN1 | |
| SCHEMBL9410554 | 0.72 | KDM4E (0.44) | TRPM8POLBLMNAKDM4ETHRB | |
| SCHEMBL9524233 | 0.71 | DHODH (0.54) | POLBLMNARAB9ASMN1; SMN2MEN1 | |
| SCHEMBL9523879 | 0.69 | GSK3B (0.53) | POLBKDM4ESMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0277791-B1 | CINNOLINE-CARBOXAMIDES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1993-06-02 | — | — | EP | disclosed |
| US-4826837-A | IMMUNOMODULATORS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-05-02 | — | — | US | disclosed |