Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.35 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.35 |
| ▸ | OPRK1 | P41145 | 2/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | ALOX15B | O15296 | 1/20 | 0.35 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9527463 | 0.82 | LCK (0.38) | GAAMEN1KMT2AHTTTP53 | |
| SCHEMBL9527340 | 0.78 | PYGL (0.40) | SMN1; SMN2MAPTMEN1KMT2ATDP1 | |
| SCHEMBL9527710 | 0.74 | KMT2A (0.37) | KDM4EGAASMN1; SMN2MAPTALDH1A1 | |
| SCHEMBL9525440 | 0.74 | NPC1 (0.49) | KDM4ESMN1; SMN2MAPTALDH1A1MEN1 | |
| SCHEMBL9524747 | 0.74 | ALDH1A1 (0.37) | KDM4ESMN1; SMN2MAPTALDH1A1OPRK1 | |
| SCHEMBL9524768 | 0.72 | TRPM8 (0.40) | TRPM8KDM4ESMN1; SMN2MAPTALDH1A1 | |
| Water SCHEMBL2493601 | 0.71 | HAVCR2 (0.43) | KDM4EMAPTALDH1A1MEN1KMT2A | |
| SCHEMBL9527884 | 0.68 | POLB (0.45) | KDM4ESMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL10642767 | 0.67 | RIPK1 (0.43) | KDM4ESMN1; SMN2MAPTALDH1A1MEN1 | |
| SCHEMBL14844650 | 0.66 | LIPE (0.40) | MEN1KMT2AHTTLIPECYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0277791-B1 | CINNOLINE-CARBOXAMIDES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1993-06-02 | — | — | EP | disclosed |
| US-4826837-A | IMMUNOMODULATORS | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-05-02 | — | — | US | disclosed |
| EP-0277791-A2 | Cinnoline-carboxamides and process for their preparation | FARMITALIA CARLO ERBA S.r.l. (IT) | 1988-08-10 | — | — | EP | disclosed |