Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 | P31645 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.43 |
| ▸ | MMP14 | P50281 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10491419 | 0.87 | TSHR (0.43) | SLC6A4MTNR1AMTNR1BLMNAMEN1 | |
| SCHEMBL9532459 | 0.86 | HTR2A (0.53) | MTNR1AMTNR1BLMNAMEN1MAPT | |
| SCHEMBL9531891 | 0.82 | HTR2A (0.43) | MTNR1AMTNR1BLMNAMEN1MAPT | |
| SCHEMBL9528741 | 0.80 | MTNR1A (0.48) | MTNR1AMTNR1BMEN1MAPTKMT2A | |
| SCHEMBL9529052 | 0.78 | LMNA (0.44) | LMNAMEN1TP53MAPTKMT2A | |
| Acetic Acid SCHEMBL9527415 | 0.76 | MTNR1A (0.51) | SLC6A4MTNR1AMTNR1BLMNAMEN1 | |
| SCHEMBL10491444 | 0.75 | KMT2A (0.51) | SLC6A4MTNR1AMTNR1BMEN1MAPT | |
| SCHEMBL10491380 | 0.73 | SMN1; SMN2 (0.53) | LMNAMEN1MAPTKMT2AHTR2A | |
| SCHEMBL10491379 | 0.72 | HTR2A (0.40) | MAPTKMT2AHTR2ASMN1; SMN2 | |
| SCHEMBL3579326 | 0.71 | RAB9A (0.70) | SLC6A4MTNR1AMTNR1BLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0287468-B1 | 17-AZA-20,21-DINOREBURNAMENINE DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1993-03-10 | — | — | EP | disclosed |
| EP-0287468-A2 | 17-Aza-20,21-dinoreburnamenine derivatives, process and intermediates for their preparation, their use as medicaments and compositions containing them | ROUSSEL-UCLAF (FR) | 1988-10-19 | — | — | EP | disclosed |