Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | SNCA | P37840 | 11/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL10491368 | 0.90 | MTNR1A (0.43) | LMNAMEN1TP53MAPTKMT2A | |
| SCHEMBL10491366 | 0.89 | KMT2A (0.43) | LMNAMEN1TP53MAPTKMT2A | |
| SCHEMBL9529850 | 0.87 | NPC1 (0.49) | LMNAMEN1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL9529587 | 0.84 | PDE4D (0.40) | LMNAKMT2ASMN1; SMN2HPGD | |
| SCHEMBL9530049 | 0.82 | KMT2A (0.45) | MEN1MAPTKMT2ASMN1; SMN2HTR6 | |
| SCHEMBL10491427 | 0.79 | SLC6A4 (0.46) | LMNAMEN1MAPTKMT2ASMN1; SMN2 | |
| SCHEMBL10491383 | 0.78 | SMN1; SMN2 (0.48) | LMNAMEN1MAPTKMT2ASMN1; SMN2 | |
| Acetic Acid SCHEMBL10491387 | 0.78 | HPGD (0.49) | LMNAMAPTTDP1SMN1; SMN2HPGD | |
| Acetic Acid SCHEMBL10491431 | 0.78 | RAB9A (0.48) | LMNAMEN1MAPTKMT2ATDP1 | |
| SCHEMBL9527410 | 0.78 | SLC6A4 (0.44) | LMNAMEN1TP53MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0527851-A1 | 1H-SUBSTITUTED-1,2,4-TRIAZOLE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. (US) | 1993-02-24 | — | — | EP | disclosed |
| US-5098920-A | Hypotensive agents and treatment of congestive heart failure | G. D. SEARLE & CO. (US) | 1992-03-24 | — | — | US | disclosed |
| WO-1991017148-A1 | 1H-SUBSTITUTED-1,2,4-TRIAZOLE COMPOUNDS FOR TREATMENT OF CARDIOVASCULAR DISORDERS | G.D. SEARLE & CO. (US) | 1991-11-14 | — | — | WO | disclosed |