Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.35 |
| ▸ | OPRL1 | P41146 | 5/20 | 0.35 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.35 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 1/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9524525 | 0.80 | RAB9A (0.36) | — | |
| SCHEMBL9523567 | 0.79 | DDB1 (0.38) | SMN1; SMN2TRPV1PFKFB3OPRD1MAPK1 | |
| SCHEMBL769246 | 0.73 | ADRA1A (0.48) | — | |
| SCHEMBL7300199 | 0.71 | EPHX2 (0.42) | SMN1; SMN2TRPV1OPRL1MEN1KMT2A | |
| SCHEMBL23746634 | 0.68 | ALDH1A1 (0.42) | SMN1; SMN2LMNATRPV1OPRD1KMT2A | |
| SCHEMBL13257631 | 0.68 | ALDH1A1 (0.42) | SMN1; SMN2LMNATRPV1OPRD1KMT2A | |
| SCHEMBL24075724 | 0.68 | ALDH1A1 (0.42) | SMN1; SMN2LMNATRPV1OPRD1KMT2A | |
| SCHEMBL11363318 | 0.68 | SLC6A2 (0.43) | LMNATRPV1PFKFB3OPRD1MAPK1 | |
| SCHEMBL15021653 | 0.66 | MEN1 (0.43) | LMNATRPV1HTR2BMEN1KMT2A | |
| SCHEMBL22997112 | 0.66 | TRPV1 (0.37) | SMN1; SMN2LMNATRPV1OPRD1HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0298452-B1 | 2H-1-BENZOPYRANE DERIVATIVES SUBSTITUTED IN POSITION 4 BY ARYL OR N-HETEROARYL | F. HOFFMANN-LA ROCHE AG (CH) | 1993-06-30 | — | — | EP | disclosed |
| US-5118694-A | Hypotensive agents; treatment for cardiovascular and muscular disorders | HOFFMANN-LA ROCHE INC. (US) | 1992-06-02 | — | — | US | disclosed |
| US-4971982-A | HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS, SMOOTH MUSCLE DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1990-11-20 | — | — | US | disclosed |
| EP-0298452-A2 | 2H-1-benzopyrane derivatives substituted in position 4 by aryl or N-heteroaryl | F. HOFFMANN-LA ROCHE AG (CH) | 1989-01-11 | — | — | EP | disclosed |