Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 3/20 | 0.37 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9524374 | 0.84 | HTR2B (0.35) | DDB1CRBNTRPV1PFKFB3SMN1; SMN2 | |
| SCHEMBL9525760 | 0.84 | TRPM5 (0.42) | DDB1CRBNTRPV1SMN1; SMN2HTR2B | |
| SCHEMBL9527547 | 0.82 | ALDH1A1 (0.40) | DDB1CRBNPFKFB3SMN1; SMN2ALDH1A1 | |
| SCHEMBL8338287 | 0.81 | ABCC9 (0.43) | KDM4E | |
| SCHEMBL8967989 | 0.81 | ABCC9 (0.43) | KDM4E | |
| SCHEMBL9524927 | 0.80 | MAPT (0.42) | SMN1; SMN2KDM4EALDH1A1HTTKMT2A | |
| SCHEMBL9527411 | 0.80 | BRD4 (0.37) | TRPV1SMN1; SMN2KDM4E | |
| SCHEMBL9524902 | 0.80 | ESR1 (0.42) | DDB1CRBNSMN1; SMN2KDM4EKMT2A | |
| SCHEMBL9523546 | 0.79 | TGFBR1 (0.39) | DDB1CRBNTRPV1SMN1; SMN2KDM4E | |
| SCHEMBL9527672 | 0.79 | SMN1; SMN2 (0.36) | TRPV1PFKFB3OPRD1SMN1; SMN2HTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0298452-B1 | 2H-1-BENZOPYRANE DERIVATIVES SUBSTITUTED IN POSITION 4 BY ARYL OR N-HETEROARYL | F. HOFFMANN-LA ROCHE AG (CH) | 1993-06-30 | — | — | EP | disclosed |
| US-5118694-A | Hypotensive agents; treatment for cardiovascular and muscular disorders | HOFFMANN-LA ROCHE INC. (US) | 1992-06-02 | — | — | US | disclosed |
| US-4971982-A | HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS, SMOOTH MUSCLE DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1990-11-20 | — | — | US | disclosed |
| EP-0298452-A2 | 2H-1-benzopyrane derivatives substituted in position 4 by aryl or N-heteroaryl | F. HOFFMANN-LA ROCHE AG (CH) | 1989-01-11 | — | — | EP | disclosed |