Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9527411 | 0.82 | BRD4 (0.37) | KDM4E | |
| SCHEMBL9524511 | 0.80 | TLR3 (0.39) | RAB9A | |
| SCHEMBL9527672 | 0.80 | SMN1; SMN2 (0.36) | — | |
| SCHEMBL9527965 | 0.77 | KCNA5 (0.35) | KDM4E | |
| SCHEMBL9524902 | 0.73 | ESR1 (0.42) | KDM4E | |
| SCHEMBL9523546 | 0.72 | TGFBR1 (0.39) | KDM4E | |
| SCHEMBL9524652 | 0.72 | KDM4E (0.35) | KDM4E | |
| SCHEMBL9527561 | 0.72 | ABCC9 (0.39) | RAB9A | |
| SCHEMBL9524954 | 0.71 | BRD4 (0.35) | RAB9AKDM4E | |
| SCHEMBL9524371 | 0.71 | KDM4E (0.42) | RAB9AKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0298452-B1 | 2H-1-BENZOPYRANE DERIVATIVES SUBSTITUTED IN POSITION 4 BY ARYL OR N-HETEROARYL | F. HOFFMANN-LA ROCHE AG (CH) | 1993-06-30 | — | — | EP | disclosed |
| US-5118694-A | Hypotensive agents; treatment for cardiovascular and muscular disorders | HOFFMANN-LA ROCHE INC. (US) | 1992-06-02 | — | — | US | disclosed |
| US-4971982-A | HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS, SMOOTH MUSCLE DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1990-11-20 | — | — | US | disclosed |
| EP-0298452-A2 | 2H-1-benzopyrane derivatives substituted in position 4 by aryl or N-heteroaryl | F. HOFFMANN-LA ROCHE AG (CH) | 1989-01-11 | — | — | EP | disclosed |