Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11102490 | 0.86 | CYP1A2 (0.51) | CYP1A2ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL7403091 | 0.85 | LMNA (0.59) | CYP1A2ALDH1A1HSD17B10LMNAKMT2A | |
| SCHEMBL30637108 | 0.83 | ALDH1A1 (0.58) | CYP1A2ALDH1A1HSD17B10LMNAKMT2A | |
| SCHEMBL16127925 | 0.81 | LMNA (0.62) | CYP1A2ALDH1A1HSD17B10LMNAKMT2A | |
| SCHEMBL11113589 | 0.80 | CYP1A2 (0.46) | CYP1A2ALDH1A1KMT2AMEN1POLB | |
| SCHEMBL28111637 | 0.80 | ALDH1A1 (0.57) | CYP1A2ALDH1A1HSD17B10LMNAKMT2A | |
| SCHEMBL12714948 | 0.80 | HPGD (0.46) | CYP1A2ALDH1A1HSD17B10LMNAKMT2A | |
| SCHEMBL13593519 | 0.80 | LMNA (0.63) | CYP1A2ALDH1A1HSD17B10LMNAKMT2A | |
| SCHEMBL11112200 | 0.79 | CYP1A2 (0.45) | CYP1A2ALDH1A1LMNAKMT2AMEN1 | |
| SCHEMBL11105521 | 0.79 | NR3C1 (0.53) | CYP1A2LMNAKDM4ETSHRHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0295051-B1 | PREPARATION OF OXOPHTHALAZINYL ACETIC ACIDS HAVING BENZOTHIAZOLE OR OTHER HETEROCYCLIC SIDE CHAINS | PFIZER INC. (US) | 1993-06-09 | — | — | EP | disclosed |
| US-4900844-A | Intermediates for the preparation of oxophthalazinyl acetic acids having benzothiazole or other heterocyclic side chains | PFIZER INC. (US) | 1990-02-13 | — | — | US | disclosed |
| US-4868301-A | Processes and intermediates for the preparation of oxophthalazinyl acetic acids having benzothiazole or other heterocyclic side chains | PFIZER INC. (US) | 1989-09-19 | — | — | US | disclosed |
| EP-0295051-A2 | Preparation of oxophthalazinyl acetic acids having benzothiazole or other heterocyclic side chains | PFIZER INC. (US) | 1988-12-14 | — | — | EP | disclosed |