Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 6/20 | 0.64 |
| ▸ | PLA2G2A | P14555 | 6/20 | 0.64 |
| ▸ | MEN1 | O00255 | 2/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.64 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.64 |
| ▸ | TRPM8 | Q7Z2W7 | 3/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.62 |
| ▸ | HTR1D | P28221 | 3/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.61 |
| ▸ | PPARG | P37231 | 1/20 | 0.60 |
| ▸ | PPARD | Q03181 | 1/20 | 0.60 |
| ▸ | PPARA | Q07869 | 1/20 | 0.60 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.59 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.56 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.55 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL853597 | 1.00 | LTA4H (0.64) | LTA4HPLA2G2AMEN1KMT2AHSP90AA1 | |
| SCHEMBL6664147 | 0.91 | ALDH1A1 (0.60) | LTA4HPLA2G2AMEN1KMT2AHSP90AA1 | |
| SCHEMBL23701834 | 0.90 | PPARG (0.68) | LTA4HPLA2G2AMEN1KMT2AHSP90AA1 | |
| SCHEMBL23701738 | 0.89 | PPARG (0.59) | LTA4HPLA2G2AMEN1KMT2AHSP90AA1 | |
| SCHEMBL6219226 | 0.89 | TRPM8 (0.70) | LTA4HPLA2G2AMEN1KMT2AHSP90AA1 | |
| SCHEMBL853652 | 0.89 | TRPM8 (0.67) | LTA4HPLA2G2AMEN1KMT2AHSP90AA1 | |
| SCHEMBL4490807 | 0.88 | PPARG (0.71) | LTA4HPLA2G2AMEN1KMT2AHSP90AA1 | |
| SCHEMBL17320596 | 0.87 | KDM4E (0.53) | LTA4HPLA2G2AMEN1KMT2AHSP90AA1 | |
| SCHEMBL15747748 | 0.87 | KDM4E (0.59) | LTA4HPLA2G2AMEN1KMT2AHSP90AA1 | |
| SCHEMBL6101212 | 0.86 | LTA4H (0.70) | LTA4HPLA2G2AMEN1KMT2AHSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4126817-A1 | SUBSTITUTED 5-HYDROXYINDOLE COMPOUNDS AS MODULATORS OF ALPHA-1 ANTITRYPSIN | Vertex Pharmaceuticals Incorporated (US) | 2023-02-08 | — | — | EP | disclosed |