Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR3 | P29371 | 5/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | GPR88 | Q9GZN0 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KLK7 | P49862 | 1/20 | 0.35 |
| ▸ | CTSK | P43235 | 1/20 | 0.35 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9529632 | 0.97 | TACR3 (0.39) | TACR3POLBGPR88 | |
| SCHEMBL9528353 | 0.88 | TACR3 (0.41) | TACR3CACNA2D1 | |
| SCHEMBL9530343 | 0.85 | POLB (0.36) | POLBKLK7CTSK | |
| SCHEMBL9527591 | 0.83 | FAAH (0.42) | TACR3GPR88 | |
| SCHEMBL9527790 | 0.83 | TACR3 (0.41) | TACR3POLBGPR88ALDH1A1CACNA2D1 | |
| SCHEMBL9529074 | 0.82 | NCEH1 (0.43) | TACR3POLBGPR88ALDH1A1CACNA2D1 | |
| SCHEMBL9527699 | 0.82 | TACR3 (0.40) | TACR3POLBGPR88CTSKCACNA2D1 | |
| SCHEMBL9528534 | 0.81 | TACR3 (0.42) | TACR3POLBGPR88CACNA2D1 | |
| SCHEMBL9528223 | 0.81 | TACR3 (0.41) | TACR3POLBGPR88CACNA2D1 | |
| SCHEMBL9530047 | 0.80 | MAPT (0.34) | GPR88ALDH1A1KLK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0319170-B1 | ACYL DERIVATIVES OF HYDROXY PYRIMIDINES | PFIZER INC. (US) | 1993-03-17 | — | — | EP | claimed |
| US-4940712-A | Derivatives of hydroxyprimidines as leukotriene synthesis inhibitors | PFIZER INC. (US) | 1990-07-10 | — | — | US | claimed |
| EP-0319170-B1 | ACYL DERIVATIVES OF HYDROXY PYRIMIDINES | PFIZER INC. (US) | 1993-03-17 | — | — | EP | disclosed |
| US-4940712-A | Derivatives of hydroxyprimidines as leukotriene synthesis inhibitors | PFIZER INC. (US) | 1990-07-10 | — | — | US | disclosed |
| WO-1989005295-A1 | ACYL DERIVATIVES OF HYDROXYPYRIMIDINES | PFIZER INC. (US) | 1989-06-15 | — | — | WO | disclosed |