Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1B | P35368 | 11/20 | 0.55 |
| ▸ | ADRA1D | P25100 | 10/20 | 0.55 |
| ▸ | ADRA1A | P35348 | 10/20 | 0.55 |
| ▸ | HTR1A | P08908 | 9/20 | 0.55 |
| ▸ | BPTF | Q12830 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 2/20 | 0.43 |
| ▸ | BRD9 | Q9H8M2 | 2/20 | 0.43 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.42 |
| ▸ | BRPF1 | P55201 | 1/20 | 0.41 |
| ▸ | BRD7 | Q9NPI1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9531556 | 0.88 | ADRA1A (0.53) | ADRA1BADRA1DADRA1AHTR1ABPTF | |
| SCHEMBL9528184 | 0.88 | ADRA1A (0.58) | ADRA1BADRA1DADRA1AHTR1ABPTF | |
| SCHEMBL9526736 | 0.86 | ADRA1A (0.62) | ADRA1BADRA1DADRA1AHTR1A | |
| SCHEMBL9531491 | 0.85 | BRD4 (0.51) | ADRA1BADRA1DADRA1AHTR1ABPTF | |
| SCHEMBL9527024 | 0.85 | BPTF (0.53) | ADRA1BADRA1DADRA1AHTR1ABPTF | |
| SCHEMBL9526613 | 0.82 | ADRA1A (0.52) | ADRA1BADRA1DADRA1AHTR1ABPTF | |
| SCHEMBL9526993 | 0.82 | ADRA1D (0.49) | ADRA1BADRA1DADRA1AHTR1ABPTF | |
| SCHEMBL9531508 | 0.82 | DRD2 (0.58) | ADRA1BADRA1DADRA1AHTR1ABPTF | |
| SCHEMBL9527851 | 0.81 | ADRA1B (0.47) | ADRA1BADRA1DADRA1AHTR1ABPTF | |
| SCHEMBL9528850 | 0.81 | BPTF (0.49) | ADRA1BADRA1DADRA1AHTR1ABPTF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0372305-B1 | PIPERAZINYLALKYL-3(2H)-PYRIDAZINONES, METHOD FOR THEIR PREPARATION AND THEIR USE AS ANTIHYPERTENSIVE AGENTS | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1993-08-04 | — | — | EP | disclosed |
| US-5034391-A | Piperazinylalkyl-3(2H)-pyridazinones and the use thereof as agents lowering blood pressure | CL PHARMA AKTIENGESELLSCHAFT (AT) | 1991-07-23 | — | — | US | disclosed |
| EP-0372305-A1 | Piperazinylalkyl-3(2H)-pyridazinones, method for their preparation and their use as antihypertensive agents | Hafslund Nycomed Pharma Aktiengesellschaft (AT) | 1990-06-13 | — | — | EP | disclosed |