SCHEMBL9529276

SCHEMBL9529276

ON=C(c1ccccn1)c1ccccc1Cc1cccc2ccccc12

nearest known ligand 0.46

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.46
MAPT P10636 3/20 0.46
HPGD P15428 1/20 0.46
HTT P42858 1/20 0.46
CYP2C19 P33261 4/20 0.46
CYP3A4 P08684 3/20 0.46
ADRA2A P08913 3/20 0.44
ADRA2B P18089 3/20 0.44
ADRA2C P18825 3/20 0.44
MAPK1 P28482 3/20 0.43
KDM4E B2RXH2 2/20 0.43
KMT2A Q03164 2/20 0.43
NPC1 O15118 1/20 0.43
RAB9A P51151 1/20 0.43
POLB P06746 1/20 0.43
AGTR1 P30556 1/20 0.43
CYP2D6 P10635 2/20 0.43
CYP1A2 P05177 2/20 0.43
CYP2C9 P11712 2/20 0.43
TAAR1 Q96RJ0 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9529562 0.81 KDM4E (0.42) HTTKDM4ENPC1RAB9AAGTR1
SCHEMBL9532029 0.81 KDM4E (0.42) ALDH1A1MAPTHPGDHTTCYP2C19
SCHEMBL10407326 0.80 CYP2C19 (0.47) ALDH1A1MAPTHPGDCYP2C19CYP3A4
SCHEMBL23366565 0.77 KDM4E (0.49) ALDH1A1MAPTHPGDHTTMAPK1
SCHEMBL9529668 0.77 KDM4E (0.47) ALDH1A1MAPTCYP2C19CYP3A4ADRA2A
SCHEMBL9532053 0.76 NPC1 (0.43) ALDH1A1MAPTHPGDHTTCYP2C19
SCHEMBL9530012 0.76 KDM4E (0.42) ALDH1A1MAPTHTTCYP2C19CYP3A4
SCHEMBL9527768 0.75 CYP2C9 (0.40) ALDH1A1HPGDHTTADRA2AADRA2B
SCHEMBL9529150 0.71 CYP4F2 (0.41) ALDH1A1MAPTHPGDHTTKDM4E
SCHEMBL9532748 0.71 POLB (0.46) ALDH1A1HTTCYP2C19CYP3A4MAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0366006-B1 PYRIDYLKETOXIME ETHER COMPOUND AND PHARMACEUTICAL COMPOSITION CONTAINING IT KAKEN PHARMACEUTICAL CO., LTD. (JP) 1993-09-29 EP disclosed
US-4971985-A ANTIISCHEMIC AGENTS, CARDIOVASCULAR DISORDERS KAKEN PHARMACEUTICAL CO., LTD. (JP) 1990-11-20 US disclosed