Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 2/20 | 0.60 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.60 |
| ▸ | MEN1 | O00255 | 5/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | MAPT | P10636 | 3/20 | 0.56 |
| ▸ | CA9 | Q16790 | 3/20 | 0.55 |
| ▸ | CA2 | P00918 | 2/20 | 0.55 |
| ▸ | CA4 | P22748 | 1/20 | 0.55 |
| ▸ | CA5A | P35218 | 1/20 | 0.55 |
| ▸ | NPC1 | O15118 | 5/20 | 0.55 |
| ▸ | RAB9A | P51151 | 4/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | FBP1 | P09467 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.55 |
| ▸ | GFER | P55789 | 1/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.55 |
| ▸ | RELA | Q04206 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9486556 | 0.88 | MEN1 (0.67) | EPHX1EPHX2MEN1KMT2AMAPT | |
| SCHEMBL9487998 | 0.86 | KMT2A (0.76) | EPHX1EPHX2MEN1KMT2AMAPT | |
| SCHEMBL9097173 | 0.86 | MEN1 (0.57) | EPHX1EPHX2MEN1KMT2AMAPT | |
| SCHEMBL9529388 | 0.83 | LMNA (0.63) | MEN1KMT2AMAPTCA9CA2 | |
| SCHEMBL8762919 | 0.83 | MEN1 (0.57) | EPHX1EPHX2MEN1KMT2AMAPT | |
| SCHEMBL7892401 | 0.82 | MEN1 (0.54) | EPHX1EPHX2MEN1KMT2AMAPT | |
| SCHEMBL9096015 | 0.82 | RAB9A (0.68) | EPHX1EPHX2MEN1KMT2AMAPT | |
| SCHEMBL7744627 | 0.82 | FBP1 (0.52) | EPHX1EPHX2MEN1KMT2AMAPT | |
| SCHEMBL7089911 | 0.81 | FLT1 (0.49) | MEN1KMT2AMAPTCA9CA2 | |
| SCHEMBL4196236 | 0.81 | LMNA (0.78) | EPHX1EPHX2MAPTCA9CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0166615-B1 | IMPROVEMENTS IN OR RELATING TO BENZENESULFONAMIDO DERIVATIVES | ELI LILLY AND COMPANY (US) | 1993-05-26 | — | — | EP | disclosed |
| US-5110830-A | Benzenesulfonamides treatment of tumors susceptible to | ELI LILLY AND COMPANY (US) | 1992-05-05 | — | — | US | disclosed |
| US-4845128-A | ANTITUMOR | ELI LILLY AND COMPANY (US) | 1989-07-04 | — | — | US | disclosed |
| EP-0166615-A2 | Improvements in or relating to benzenesulfonamido derivatives | ELI LILLY AND COMPANY (US) | 1986-01-02 | — | — | EP | disclosed |