Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 2/20 | 0.40 |
| ▸ | PDE4A | P27815 | 1/20 | 0.40 |
| ▸ | PDE6C | P51160 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.40 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.40 |
| ▸ | DNMT1 | P26358 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.39 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.39 |
| ▸ | CDK4 | P11802 | 1/20 | 0.39 |
| ▸ | CCND1 | P24385 | 1/20 | 0.39 |
| ▸ | HTR2A | P28223 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10491405 | 0.91 | KMT2A (0.46) | PDE4DPDE4APDE6CPDE4BPDE4C | |
| Acetic Acid SCHEMBL10491411 | 0.90 | HPGD (0.40) | PDE4DPDE4APDE6CPDE4BPDE4C | |
| SCHEMBL9530049 | 0.89 | KMT2A (0.45) | ACHECDK4CCND1HTR2AHPGD | |
| SCHEMBL9529052 | 0.84 | LMNA (0.44) | HPGDSMN1; SMN2LMNAKMT2A | |
| SCHEMBL9529850 | 0.84 | NPC1 (0.49) | ACHEHTR2AHTR1ARAB9ASMN1; SMN2 | |
| SCHEMBL10491367 | 0.82 | KMT2A (0.42) | ACHECDK4CCND1HTR2AHTR1A | |
| SCHEMBL10491383 | 0.82 | SMN1; SMN2 (0.48) | DNMT1ADRA2AADRA2BADRA2CADRA1D | |
| Acetic Acid SCHEMBL10491387 | 0.80 | HPGD (0.49) | DNMT1ADRA2AADRA2BADRA2CADRA1D | |
| Acetic Acid SCHEMBL10491372 | 0.80 | MTNR1A (0.45) | ACHECDK4CCND1HTR2AHPGD | |
| SCHEMBL9531891 | 0.78 | HTR2A (0.43) | PDE4DPDE4APDE6CPDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0287468-B1 | 17-AZA-20,21-DINOREBURNAMENINE DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1993-03-10 | — | — | EP | disclosed |
| EP-0287468-A2 | 17-Aza-20,21-dinoreburnamenine derivatives, process and intermediates for their preparation, their use as medicaments and compositions containing them | ROUSSEL-UCLAF (FR) | 1988-10-19 | — | — | EP | disclosed |