Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9530049 | 0.93 | KMT2A (0.45) | NPC1RAB9AHTR2AKMT2AHTR1A | |
| SCHEMBL10491427 | 0.91 | SLC6A4 (0.46) | NPC1RAB9AHTR2ASLC6A4KMT2A | |
| Acetic Acid SCHEMBL10491431 | 0.91 | RAB9A (0.48) | NPC1RAB9AHTR2ASLC6A4KMT2A | |
| SCHEMBL9529052 | 0.87 | LMNA (0.44) | KMT2AMAPTMEN1LMNASMN1; SMN2 | |
| SCHEMBL10491367 | 0.85 | KMT2A (0.42) | NPC1RAB9AHTR2ASLC6A4KMT2A | |
| Acetic Acid SCHEMBL10491372 | 0.84 | MTNR1A (0.45) | NPC1RAB9AHTR2AKMT2AHTR1A | |
| SCHEMBL9529587 | 0.84 | PDE4D (0.40) | RAB9AHTR2AKMT2AHTR1ALMNA | |
| SCHEMBL10491366 | 0.81 | KMT2A (0.43) | RAB9AKMT2AMAPTMEN1LMNA | |
| SCHEMBL10491383 | 0.80 | SMN1; SMN2 (0.48) | RAB9AHTR2AKMT2AHTR1AKDM4E | |
| SCHEMBL9532459 | 0.79 | HTR2A (0.53) | NPC1RAB9AHTR2AKMT2AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0287468-B1 | 17-AZA-20,21-DINOREBURNAMENINE DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1993-03-10 | — | — | EP | disclosed |
| EP-0287468-A2 | 17-Aza-20,21-dinoreburnamenine derivatives, process and intermediates for their preparation, their use as medicaments and compositions containing them | ROUSSEL-UCLAF (FR) | 1988-10-19 | — | — | EP | disclosed |