Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 2/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.41 |
| ▸ | CCND1 | P24385 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9529850 | 0.93 | NPC1 (0.49) | KMT2AMEN1MAPTACHEHTR2A | |
| SCHEMBL10491367 | 0.91 | KMT2A (0.42) | KMT2AMEN1MAPTMTNR1AMTNR1B | |
| Acetic Acid SCHEMBL10491372 | 0.91 | MTNR1A (0.45) | KMT2AMEN1MAPTMTNR1AMTNR1B | |
| SCHEMBL9529587 | 0.89 | PDE4D (0.40) | KMT2AACHEHTR2ACDK4CCND1 | |
| SCHEMBL10491427 | 0.85 | SLC6A4 (0.46) | KMT2AMEN1MAPTACHEHTR2A | |
| Acetic Acid SCHEMBL10491431 | 0.84 | RAB9A (0.48) | KMT2AMEN1MAPTMTNR1AMTNR1B | |
| SCHEMBL9529052 | 0.82 | LMNA (0.44) | KMT2AMEN1MAPTHTR6HPGD | |
| SCHEMBL10491405 | 0.82 | KMT2A (0.46) | KMT2AACHEHPGDSMN1; SMN2 | |
| Acetic Acid SCHEMBL10491411 | 0.80 | HPGD (0.40) | MAPTACHEHTR2ACDK4CCND1 | |
| SCHEMBL10491383 | 0.80 | SMN1; SMN2 (0.48) | KMT2AMEN1MAPTHTR2AHTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0287468-B1 | 17-AZA-20,21-DINOREBURNAMENINE DERIVATIVES, PROCESS AND INTERMEDIATES FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1993-03-10 | — | — | EP | disclosed |
| EP-0287468-A2 | 17-Aza-20,21-dinoreburnamenine derivatives, process and intermediates for their preparation, their use as medicaments and compositions containing them | ROUSSEL-UCLAF (FR) | 1988-10-19 | — | — | EP | disclosed |