Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 4/20 | 0.53 |
| ▸ | DRD4 | P21917 | 1/20 | 0.53 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.34 |
| ▸ | MAOA | P21397 | 2/20 | 0.33 |
| ▸ | MAOB | P27338 | 2/20 | 0.33 |
| ▸ | DRD1 | P21728 | 2/20 | 0.32 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
| ▸ | DRD3 | P35462 | 2/20 | 0.31 |
| ▸ | PRKCI | P41743 | 1/20 | 0.31 |
| ▸ | DRD5 | P21918 | 1/20 | 0.31 |
| ▸ | TYR | P14679 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14599092 | 0.74 | DRD2 (0.46) | DRD2DRD4ESR2ESR1HSP90AA1 | |
| SCHEMBL11603388 | 0.72 | DRD2 (0.42) | DRD2DRD4ESR2ESR1MAOA | |
| SCHEMBL448757 | 0.71 | ALOX15 (0.43) | HSP90AA1HSD17B10 | |
| SCHEMBL9453911 | 0.71 | DRD2 (0.41) | DRD2DRD4ESR2ESR1MAOA | |
| SCHEMBL59263 | 0.69 | DRD2 (1.00) | DRD2DRD4ESR2ESR1HSP90AA1 | |
| Hydrochloric Acid SCHEMBL3900412 | 0.68 | DRD2 (0.96) | DRD2DRD4ESR2ESR1HSP90AA1 | |
| SCHEMBL9404389 | 0.67 | HRH3 (0.33) | MAOAMAOB | |
| SCHEMBL1176363 | 0.67 | DRD2 (0.37) | DRD2DRD4ESR2MAOAMAOB | |
| SCHEMBL29722558 | 0.67 | DRD2 (0.78) | DRD2DRD4ESR2ESR1MAOA | |
| SCHEMBL532839 | 0.67 | DRD2 (0.78) | DRD2DRD4ESR2ESR1MAOA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0331130-B1 | CARBAMIC ACID ESTER OF SUBSTITUTED 7-HYDROXY-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINES | NOVO NORDISK A/S (DK) | 1993-09-29 | — | — | EP | claimed |
| EP-0331130-B1 | CARBAMIC ACID ESTER OF SUBSTITUTED 7-HYDROXY-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINES | NOVO NORDISK A/S (DK) | 1993-09-29 | — | — | EP | disclosed |
| EP-0331130-A1 | Carbamic acid ester of substituted 7-hydroxy-2,3,4,5-tetrahydro-1H-3-benzazepines | NOVO NORDISK A/S (DK) | 1989-09-06 | — | — | EP | disclosed |