Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | PDE7A | Q13946 | 4/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | CNR2 | P34972 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 1/20 | 0.32 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9529728 | 0.85 | CNR2 (0.42) | TSHRMEN1KMT2APDE7ASMN1; SMN2 | |
| SCHEMBL9532407 | 0.82 | GRM5 (0.36) | TSHRMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL9530317 | 0.76 | MEN1 (0.40) | TSHRMEN1KMT2AALDH1A1HPGD | |
| SCHEMBL9529724 | 0.71 | LRRK2 (0.38) | TSHRPDE7AALDH1A1HPGDCES1 | |
| SCHEMBL9587447 | 0.70 | TSHR (0.40) | TSHRMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL9530870 | 0.68 | PGR (0.41) | SMN1; SMN2ALDH1A1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL9588069 | 0.65 | CA1 (0.38) | TSHRMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL9587860 | 0.65 | CA1 (0.38) | TSHRMEN1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL16197593 | 0.65 | HSD17B10 (0.50) | NPC1RAB9ATSHRMEN1KMT2A | |
| SCHEMBL9529816 | 0.64 | ABCC9 (0.41) | PDE7ACYP1A2CYP2D6CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0214743-B1 | USE OF QUINOLINE DERIVATIVES IN THE MANUFACTURE OF MEDICAMENTS FOR THE TREATMENT OF CEREBROVASCULAR DISORDERS AND CEREBRAL SENILITY | BEECHAM GROUP PLC (GB) | 1993-05-12 | — | — | EP | claimed |