Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 3/20 | 0.36 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.32 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.32 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.32 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.32 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9530888 | 0.82 | NPC1 (0.35) | GRM5GRM1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL9529728 | 0.82 | CNR2 (0.42) | GRM5GRM1CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL9530870 | 0.75 | PGR (0.41) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| SCHEMBL9529724 | 0.68 | LRRK2 (0.38) | LMNATSHRALDH1A1HPGD | |
| SCHEMBL9530317 | 0.68 | MEN1 (0.40) | LMNATSHRALDH1A1HPGDMEN1 | |
| SCHEMBL9587447 | 0.67 | TSHR (0.40) | CYP1A2CYP2D6CYP2C9CYP2C19LMNA | |
| SCHEMBL5667100 | 0.66 | ALDH1A1 (0.49) | LMNADRD2SMN1; SMN2ALDH1A1HPGD | |
| SCHEMBL27807504 | 0.65 | CNR2 (0.42) | JAK2TYK2CYP1A2CYP2D6CYP2C9 | |
| SCHEMBL9587908 | 0.64 | ABCC9 (0.41) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 | |
| SCHEMBL9139375 | 0.64 | PDE4A (0.52) | ABCC9ABCC8KCNJ11KCNJ8CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0214743-B1 | USE OF QUINOLINE DERIVATIVES IN THE MANUFACTURE OF MEDICAMENTS FOR THE TREATMENT OF CEREBROVASCULAR DISORDERS AND CEREBRAL SENILITY | BEECHAM GROUP PLC (GB) | 1993-05-12 | — | — | EP | claimed |