Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.38 |
| ▸ | PGR | P06401 | 7/20 | 0.38 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | G6PD | P11413 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | TGM2 | P21980 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9529724 | 0.85 | LRRK2 (0.38) | LRRK2PGRNR3C1ARHSD17B10 | |
| SCHEMBL9530870 | 0.82 | PGR (0.41) | LRRK2PGRNR3C1ARHSD17B10 | |
| SCHEMBL9588069 | 0.78 | CA1 (0.38) | MEN1KMT2ALRRK2HSD17B10LMNA | |
| SCHEMBL9587860 | 0.78 | CA1 (0.38) | MEN1KMT2ALRRK2HSD17B10LMNA | |
| SCHEMBL9530888 | 0.76 | NPC1 (0.35) | MEN1KMT2AHSD17B10LMNACES1 | |
| SCHEMBL9529728 | 0.71 | CNR2 (0.42) | MEN1KMT2AMAPTLMNATGM2 | |
| SCHEMBL9735249 | 0.70 | POLB (0.33) | MEN1KMT2AHSD17B10KDM4EMAPT | |
| SCHEMBL9532407 | 0.68 | GRM5 (0.36) | MEN1KMT2ALMNABRD4ALDH1A1 | |
| SCHEMBL3381466 | 0.68 | KDM4E (0.69) | MEN1KMT2APGRNR3C1AR | |
| SCHEMBL9846729 | 0.65 | BACE1 (0.37) | MEN1KMT2AHSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0214743-B1 | USE OF QUINOLINE DERIVATIVES IN THE MANUFACTURE OF MEDICAMENTS FOR THE TREATMENT OF CEREBROVASCULAR DISORDERS AND CEREBRAL SENILITY | BEECHAM GROUP PLC (GB) | 1993-05-12 | — | — | EP | claimed |
| US-4808619-A | HYPOTENSIVE AGENT, COGNITION ACTIVATOR | BEECHAM GROUP P.L.C. (GB) | 1989-02-28 | — | — | US | claimed |
| EP-0214743-A2 | Use of quinoline derivatives in the manufacture of medicaments for the treatment of cerebrovascular disorders and cerebral senility | BEECHAM GROUP PLC (GB) | 1987-03-18 | — | — | EP | claimed |
| EP-0288196-B1 | Sulfonyldecahydro-8H-isoquino[2,1-g][1,6]naphthyridines, optical isomers thereof and related compounds | SYNTEX (U.S.A.) INC. (US) | 1993-07-28 | — | — | EP | disclosed |
| EP-0214743-B1 | USE OF QUINOLINE DERIVATIVES IN THE MANUFACTURE OF MEDICAMENTS FOR THE TREATMENT OF CEREBROVASCULAR DISORDERS AND CEREBRAL SENILITY | BEECHAM GROUP PLC (GB) | 1993-05-12 | — | — | EP | disclosed |
| US-4886798-A | Optical isomers of sulfonyldecahydro-8H-isoquino-(2,1-G)(1,6) naphthyridines and related compounds useful as α2 -blockers | SYNTEX (U.S.A.) INC. (US) | 1989-12-12 | — | — | US | disclosed |
| US-4808619-A | HYPOTENSIVE AGENT, COGNITION ACTIVATOR | BEECHAM GROUP P.L.C. (GB) | 1989-02-28 | — | — | US | disclosed |
| EP-0214743-A2 | Use of quinoline derivatives in the manufacture of medicaments for the treatment of cerebrovascular disorders and cerebral senility | BEECHAM GROUP PLC (GB) | 1987-03-18 | — | — | EP | disclosed |