Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.38 |
| ▸ | PGR | P06401 | 5/20 | 0.38 |
| ▸ | AR | P10275 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | G6PD | P11413 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | GFER | P55789 | 1/20 | 0.36 |
| ▸ | TGM2 | P21980 | 1/20 | 0.35 |
| ▸ | CES1 | P23141 | 1/20 | 0.35 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9530317 | 0.85 | MEN1 (0.40) | LRRK2PGRARKDM4EMAPT | |
| SCHEMBL9530870 | 0.82 | PGR (0.41) | LRRK2PGRARKDM4EMAPT | |
| SCHEMBL9589108 | 0.78 | LMNA (0.34) | MAPTHSD17B10LMNAHPGDTSHR | |
| SCHEMBL10758064 | 0.76 | PSEN1 (0.37) | MAPTHSD17B10LMNATP53HPGD | |
| SCHEMBL9529728 | 0.76 | CNR2 (0.42) | MAPTLMNATGM2CES1PDE7A | |
| SCHEMBL9530888 | 0.71 | NPC1 (0.35) | HSD17B10LMNACES1PDE7AHPGD | |
| SCHEMBL10840367 | 0.69 | KDM4E (0.47) | PGRARKDM4EMAPTHSD17B10 | |
| SCHEMBL9532407 | 0.68 | GRM5 (0.36) | LMNAHPGDALDH1A1TSHR | |
| SCHEMBL10840490 | 0.68 | ALDH1A1 (0.69) | PGRARKDM4EMAPTHSD17B10 | |
| SCHEMBL9846715 | 0.65 | CTSD (0.36) | KDM4EMAPTLMNATP53HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0214743-B1 | USE OF QUINOLINE DERIVATIVES IN THE MANUFACTURE OF MEDICAMENTS FOR THE TREATMENT OF CEREBROVASCULAR DISORDERS AND CEREBRAL SENILITY | BEECHAM GROUP PLC (GB) | 1993-05-12 | — | — | EP | claimed |
| EP-0150202-B1 | DI/TETRA-HYDROQUINOLINES | BEECHAM GROUP PLC (GB) | 1988-07-06 | — | — | EP | claimed |
| EP-0214743-A2 | Use of quinoline derivatives in the manufacture of medicaments for the treatment of cerebrovascular disorders and cerebral senility | BEECHAM GROUP PLC (GB) | 1987-03-18 | — | — | EP | claimed |
| EP-0150202-A1 | DI/TETRA-HYDROQUINOLINES. | BEECHAM GROUP PLC (GB) | 1985-08-07 | — | — | EP | claimed |
| WO-1985000602-A1 | DI/TETRA-HYDROQUINOLINES | BEECHAM GROUP P.L.C. (GB) | 1985-02-14 | — | — | WO | claimed |
| EP-0214743-B1 | USE OF QUINOLINE DERIVATIVES IN THE MANUFACTURE OF MEDICAMENTS FOR THE TREATMENT OF CEREBROVASCULAR DISORDERS AND CEREBRAL SENILITY | BEECHAM GROUP PLC (GB) | 1993-05-12 | — | — | EP | disclosed |
| US-4808619-A | HYPOTENSIVE AGENT, COGNITION ACTIVATOR | BEECHAM GROUP P.L.C. (GB) | 1989-02-28 | — | — | US | disclosed |
| US-4798619-A | 2-(2-imidazolin-2-yl)-pyridines and quinolines and use of said compounds as herbicidal agents | AMERICAN CYANAMID CO. (US) | 1989-01-17 | — | — | US | disclosed |
| EP-0150202-B1 | DI/TETRA-HYDROQUINOLINES | BEECHAM GROUP PLC (GB) | 1988-07-06 | — | — | EP | disclosed |
| EP-0214743-A2 | Use of quinoline derivatives in the manufacture of medicaments for the treatment of cerebrovascular disorders and cerebral senility | BEECHAM GROUP PLC (GB) | 1987-03-18 | — | — | EP | disclosed |
| EP-0150202-A1 | DI/TETRA-HYDROQUINOLINES. | BEECHAM GROUP PLC (GB) | 1985-08-07 | — | — | EP | disclosed |
| WO-1985000602-A1 | DI/TETRA-HYDROQUINOLINES | BEECHAM GROUP P.L.C. (GB) | 1985-02-14 | — | — | WO | disclosed |