Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.34 |
| ▸ | KDM1A | O60341 | 4/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 4/20 | 0.33 |
| ▸ | MAOA | P21397 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | EBP | Q15125 | 1/20 | 0.30 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9533119 | 0.86 | MAOB (0.35) | SIGMAR1KDM1AMAOBKMT2AKDM4E | |
| SCHEMBL9531388 | 0.82 | ALOX12 (0.36) | KDM1AALOX12MAOBMAOAKMT2A | |
| SCHEMBL9531785 | 0.81 | SIGMAR1 (0.35) | SIGMAR1KDM1AMAOBMAOAEBP | |
| SCHEMBL7883341 | 0.74 | MAOB (0.39) | SIGMAR1KDM1AMAOB | |
| SCHEMBL9532323 | 0.73 | MAOB (0.36) | SIGMAR1KDM1AMAOBKDM4E | |
| SCHEMBL9530955 | 0.71 | KMT2A (0.38) | ALOX12KMT2AKDM4EGAA | |
| SCHEMBL9532066 | 0.71 | ALOX12 (0.34) | KDM1AALOX12MAOBMAOAKMT2A | |
| SCHEMBL10962460 | 0.68 | AKT1 (0.44) | SIGMAR1KMT2A | |
| SCHEMBL9536178 | 0.68 | HTR1A (0.31) | SIGMAR1 | |
| SCHEMBL7782464 | 0.66 | ESR2 (0.48) | SIGMAR1KDM1AMAOBEBPESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0314852-B1 | Process for the preparation of 1-substituted imidazole-carbonic acid and derivatives | CIBA GEIGY AG (CH) | 1993-11-18 | — | — | EP | disclosed |
| US-4921955-A | Process for the synthesis of 1-substituted imidazole-5-carboxylic acids and carboxylic acid derivatives | CIBA-GEIGY CORPORATION (US) | 1990-05-01 | — | — | US | disclosed |
| EP-0314852-A2 | Process for the preparation of 1-substituted imidazole-carbonic acid and derivatives | CIBA-GEIGY AG (CH) | 1989-05-10 | — | — | EP | disclosed |