Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 1/20 | 0.56 |
| ▸ | GRIN2B | Q13224 | 3/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.41 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.41 |
| ▸ | DRD2 | P14416 | 2/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 2/20 | 0.39 |
| ▸ | RB1 | P06400 | 2/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.37 |
| ▸ | ACHE | P22303 | 1/20 | 0.36 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9531900 | 0.82 | MTNR1A (0.60) | FYNGRIN2BMTNR1AMTNR1BDRD2 | |
| SCHEMBL10340214 | 0.82 | MTNR1A (0.47) | FYNMTNR1AMTNR1BDRD2DRD3 | |
| SCHEMBL10340392 | 0.78 | MTNR1A (0.50) | MTNR1AMTNR1BMAOA | |
| SCHEMBL6075588 | 0.73 | MTNR1A (0.72) | MTNR1AMTNR1BMAOA | |
| SCHEMBL9532235 | 0.72 | MTNR1A (0.53) | GRIN2BMTNR1AMTNR1BDRD2DRD3 | |
| SCHEMBL3834622 | 0.70 | GRIN2B (0.77) | FYNGRIN2BDRD2DRD3HDAC1 | |
| SCHEMBL10340613 | 0.70 | MAOA (0.48) | FYNMTNR1AMTNR1BDRD2DRD3 | |
| Hydrochloric Acid SCHEMBL10446804 | 0.69 | GRIN2B (0.74) | FYNGRIN2BDRD2DRD3ACHE | |
| SCHEMBL8891187 | 0.68 | HTR1A (0.45) | MTNR1AMTNR1BDRD2DRD3MAOA | |
| SCHEMBL10043005 | 0.68 | DRD2 (0.71) | FYNGRIN2BDRD2DRD3RB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0162695-B1 | 6-OXYGENATED-1,3,,4,5-TETRAHYDROBENZ(CD)INDOL-4-AMINES | SMITHKLINE BEECHAM CORPORATION (US) | 1990-01-17 | — | — | EP | disclosed |
| EP-0162695-A1 | 6-Oxygenated-1,3,,4,5-Tetrahydrobenz(cd)indol-4-amines | SMITHKLINE BEECHAM CORPORATION (US) | 1985-11-27 | — | — | EP | disclosed |