Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 6/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.40 |
| ▸ | PTGES | O14684 | 2/20 | 0.39 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CASP3 | P42574 | 1/20 | 0.38 |
| ▸ | BLM | P54132 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.38 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.38 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1839904 | 0.86 | PTGES (0.52) | PTGS2PTGS1ALOX5PTGESALOX5AP | |
| SCHEMBL6477263 | 0.72 | PTGS2 (0.71) | PTGS2PTGS1ALOX5KMT2A | |
| SCHEMBL7559353 | 0.71 | ALOX5 (0.36) | PTGS2PTGS1ALOX5PTGESALOX5AP | |
| SCHEMBL9536280 | 0.71 | ALOX5 (0.48) | PTGS2PTGS1ALOX5PTGESALOX5AP | |
| SCHEMBL6290796 | 0.66 | MAPK14 (0.42) | — | |
| SCHEMBL6187785 | 0.64 | PTGS1 (0.43) | PTGS2PTGS1ALOX5PTGESALOX5AP | |
| SCHEMBL27649740 | 0.63 | PTGS2 (0.57) | PTGS2PTGS1 | |
| SCHEMBL9267895 | 0.62 | NPC1 (0.36) | PTGS2PTGS1ALOX5PTGESALOX5AP | |
| SCHEMBL18241028 | 0.61 | PTGS2 (0.55) | PTGS2PTGS1 | |
| Hydrogen Sulfide SCHEMBL27719947 | 0.61 | PTGS2 (0.55) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0397175-B1 | Substituted pyrrolizine compounds and theit use as pharmaceuticals | DANNHARDT GERD PROF DR (DE) | 1993-12-08 | — | — | EP | disclosed |