Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGES | O14684 | 6/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 5/20 | 0.52 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.52 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.52 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9532669 | 0.86 | PTGS2 (0.43) | PTGESPTGS1PTGS2ALOX5ALOX5AP | |
| SCHEMBL5561244 | 0.85 | TP53 (0.42) | PTGESPTGS1PTGS2ALOX5ALOX5AP | |
| SCHEMBL9463171 | 0.84 | NPC1 (0.42) | PTGESPTGS1PTGS2ALOX5ALOX5AP | |
| SCHEMBL5561554 | 0.78 | PTGS1 (0.39) | PTGESPTGS1PTGS2ALOX5ALOX5AP | |
| SCHEMBL6187785 | 0.77 | PTGS1 (0.43) | PTGESPTGS1PTGS2ALOX5ALOX5AP | |
| SCHEMBL10026721 | 0.75 | PTGES (0.65) | PTGESPTGS1PTGS2ALOX5ALOX5AP | |
| SCHEMBL4695135 | 0.74 | PTGES (0.51) | PTGESPTGS1PTGS2ALOX5ALOX5AP | |
| SCHEMBL6503450 | 0.74 | PTGES (0.67) | PTGESPTGS1PTGS2ALOX5ALOX5AP | |
| SCHEMBL6025084 | 0.74 | PTGES (0.51) | PTGESPTGS1PTGS2ALOX5ALOX5AP | |
| SCHEMBL13653067 | 0.74 | PTGES (0.77) | PTGESPTGS1PTGS2ALOX5ALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 42 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3324959-B1 | LICOFELONE DERIVATIVES AND METHODS OF USE | UNIV OKLAHOMA (US) | 2023-07-12 | — | — | EP | disclosed |
| US-8034837-B2 | Polymorphic form of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1h-pyrrolizin-5-ylacetic acid | MERCKLE GMBH (DE) | 2011-10-11 | — | — | US | disclosed |
| US-8034837-B2 | Polymorphic form of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1h-pyrrolizin-5-ylacetic acid | MERCKLE GMBH (DE) | 2011-10-11 | — | — | US | disclosed |
| US-8034837-B2 | Polymorphic form of 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1h-pyrrolizin-5-ylacetic acid | MERCKLE GMBH (DE) | 2011-10-11 | — | — | US | disclosed |
| EP-1861404-B1 | POLYMORPHIC FORM OF 6- (4-CHLOROPHENYL) -2, 2-DIMETHYL-7-PHENYL-2, 3-DIHYDRO-LH-PYRROLIZIN-5-YLACETIC ACID | MERCKLE GMBH (DE) | 2011-05-18 | — | — | EP | disclosed |
| CN-101160311-B | Polymorphic form of 6- (4-chlorophenyl) -2, 2-dimethyl-7-phenyl-2, 3-dihydro-lh-pyrrolizin-5-ylacetic acid | MERCKLE GMBH | 2010-11-24 | — | — | CN | disclosed |
| US-20090209610-A1 | Polymorphic form of 6-(4-chlorophenyl)-2,2-dimethyl-7-Phenyl-2,3-Dihydro-1h-Pyrrolizin-5-Ylacetic Acid | MERCKLE GMGH (DE) | 2009-08-20 | — | — | US | disclosed |
| US-20090209610-A1 | Polymorphic form of 6-(4-chlorophenyl)-2,2-dimethyl-7-Phenyl-2,3-Dihydro-1h-Pyrrolizin-5-Ylacetic Acid | MERCKLE GMGH (DE) | 2009-08-20 | — | — | US | disclosed |
| US-20090209610-A1 | Polymorphic form of 6-(4-chlorophenyl)-2,2-dimethyl-7-Phenyl-2,3-Dihydro-1h-Pyrrolizin-5-Ylacetic Acid | MERCKLE GMGH (DE) | 2009-08-20 | — | — | US | disclosed |
| WO-2009056077-A3 | A NEW METHOD OF MANUFACTURING 2-(6-(4-CHLOROPHENYL)-2,2-DIMETHYL-7-PHENYL-2,3-DIHYDRO-LH-PYRROLIZINE-5-YL)ACETIC ACID (LICOFELONE) | ZENTIVA AS (CZ) | 2009-06-18 | — | — | WO | disclosed |
| EP-1252164-B1 | METHOD FOR PRODUCING 6-(4-CHLOROPHENYL)-2,2-DIMETHYL-7-PHENYL-2,3-DIHYDRO-1H-PYRROLIZINE-5-YL ACETIC ACID | MERCKLE GMBH (DE) | 2004-03-24 | — | — | EP | disclosed |
| EP-1398315-A1 | Anti-inflammatory oxo-derivatives and hydroxy derivatives of pyrrolizines, and their pharmaceutical use | MERCKLE GMBH (DE) | 2004-03-17 | — | — | EP | disclosed |
| EP-1232158-B1 | ANTI-INFLAMMATORY OXO DERIVATIVES AND HYDROXY DERIVATIVES OF PYRROLIZINES, AND THEIR PHARMACEUTICAL USE | MERCKLE GMBH (DE) | 2004-02-25 | — | — | EP | disclosed |
| WO-2003018583-A1 | METHOD FOR THE PRODUCTION OF 6-(4-CHLOROPHENYL)-2,2-DIMETHYL-7-PHENYL-2,3-DIHYDRO-1H-PYRROLIZIN-5-YLACETIC ACID | MERCKLE GMBH (DE) | 2003-03-06 | — | — | WO | disclosed |
| WO-2003018583-A1 | METHOD FOR THE PRODUCTION OF 6-(4-CHLOROPHENYL)-2,2-DIMETHYL-7-PHENYL-2,3-DIHYDRO-1H-PYRROLIZIN-5-YLACETIC ACID | MERCKLE GMBH (DE) | 2003-03-06 | — | — | WO | disclosed |
| EP-1252164-A1 | METHOD FOR PRODUCING 6-(4-CHLOROPHENYL)-2,2-DIMETHYL-7-PHENYL-2,3-DIHYDRO-1H-PYRROLIZINE-5-YL ACETIC ACID | MERCKLE GMBH (DE) | 2002-10-30 | — | — | EP | disclosed |
| WO-2001005792-A9 | ANTI-INFLAMMATORY OXO DERIVATIVES AND HYDROXY DERIVATIVES OF PYRROLIZINES, AND THEIR PHARMACEUTICAL USE | MERCKLE GMBH (DE) | 2002-08-29 | — | — | WO | disclosed |
| US-6417371-B1 | THREE PHASE WATER/OIL/ETHER SYSTEM IS CREATED; COMPOUND IS REMOVED BY ACIDIFICATION OF MIDDLE PHASE CONTAINING ITS SALT | MERCKLE GMBH (DE) | 2002-07-09 | — | — | US | disclosed |
| US-20020028953-A1 | Process for preparing 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl-acetic acid | MERCKLE GMBH (DE) | 2002-03-07 | — | — | US | disclosed |
| WO-2001055149-A1 | METHOD FOR PRODUCING 6-(4-CHLOROPHENYL)-2,2-DIMETHYL-7-PHENYL-2,3-DIHYDRO-1H-PYRROLIZINE-5-YL ACETIC ACID | MERCKLE GMBH (DE) | 2001-08-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020028953-A1 | Process for preparing 6-(4-chlorophenyl)-2,2-dimethyl-7-phenyl-2,3-dihydro-1H-pyrrolizin-5-yl-acetic acid | HPD, OGDH, OTC | PTGES 1059/4885PTGS1 384/4885PTGS2 247/4885 |
| US-20090209610-A1 | Polymorphic form of 6-(4-chlorophenyl)-2,2-dimethyl-7-Phenyl-2,3-Dihydro-1h-Pyrrolizin-5-Ylacetic Acid | CYP2D6, DDC, HLA-DRB1 | PTGES 1876/4885PTGS1 3866/4885PTGS2 2358/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.