Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASR | P41180 | 10/20 | 0.59 |
| ▸ | HTR1A | P08908 | 3/20 | 0.54 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 3/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9455227 | 0.99 | CASR (0.58) | CASRHTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL9529217 | 0.83 | HTR1A (0.61) | CASRHTR1AADRA1DADRA1AADRA1B | |
| Hydrochloric Acid SCHEMBL9455126 | 0.82 | HTR1A (0.60) | CASRHTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL6977935 | 0.80 | CASR (0.50) | CASRHTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL9529252 | 0.80 | CASR (0.50) | CASRHTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL9455114 | 0.80 | CASR (0.50) | CASRHTR1AADRA1DADRA1AADRA1B | |
| SCHEMBL9699321 | 0.79 | HTR6 (0.43) | CASRHTR1AADRA1AHTR6 | |
| Hydrochloric Acid SCHEMBL9455268 | 0.79 | CASR (0.49) | CASRHTR1AGRM2 | |
| SCHEMBL9701358 | 0.75 | HTR6 (0.41) | CASRHTR1AADRA1AHTR6 | |
| SCHEMBL12614493 | 0.75 | CASR (1.00) | CASR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0359790-B1 | 1,4-BENZOXAZINE AND 1,4-BENZOTHIAZINE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | ERBA CARLO SPA (IT) | 1993-11-03 | — | — | EP | disclosed |
| US-5084454-A | Tranquilizers and antinausea drugs | FARMITALIA CARLO ERBA S.R.L. (IT) | 1992-01-28 | — | — | US | disclosed |
| EP-0359790-A1 | 1,4-BENZOXAZINE AND 1,4-BENZOTHIAZINE DERIVATIVES AND PROCESS FOR THEIR PREPARATION. | ERBA CARLO SPA (IT) | 1990-03-28 | — | — | EP | disclosed |
| WO-1989007596-A1 | NEW 1,4-BENZOXAZINE AND 1,4-BENZOTHIAZINE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-08-24 | — | — | WO | disclosed |