Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 3/20 | 0.42 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.42 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.42 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | CDYL | Q9Y232 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 2/20 | 0.33 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9536308 | 1.00 | ADRA2A (0.42) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL9535598 | 0.90 | ADRA1D (0.56) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL9535603 | 0.90 | ADRA1D (0.56) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL9534421 | 0.80 | HTR6 (0.40) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL9534428 | 0.80 | HTR6 (0.40) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL9535318 | 0.80 | ADRA1A (0.39) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL9535323 | 0.80 | ADRA1A (0.39) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL9534638 | 0.79 | KMT2A (0.38) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL9534646 | 0.79 | KMT2A (0.38) | ADRA2AADRA1AADRA2BADRA2CADRA1D | |
| SCHEMBL9534446 | 0.73 | ADRA1D (0.61) | ADRA2AADRA1AADRA2BADRA2CADRA1D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0384677-B1 | Alpha-adrenergic receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 1993-12-01 | — | — | EP | disclosed |
| US-4981848-A | CARDIOVASCULAR, HYPOTENSIVE, ANTIDEPRESSANT | SMITHKLINE BEECHAM CORPORATION (US) | 1991-01-01 | — | — | US | disclosed |
| EP-0384677-A1 | Alpha-adrenergic receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1990-08-29 | — | — | EP | disclosed |