Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | RHEB | Q15382 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ITGB2 | P05107 | 4/20 | 0.37 |
| ▸ | ICAM1 | P05362 | 4/20 | 0.37 |
| ▸ | ITGAL | P20701 | 4/20 | 0.37 |
| ▸ | DHFR | P00374 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9534194 | 0.79 | DHFR (0.45) | CYP1A2GAAALDH1A1KDM4EPKM | |
| SCHEMBL9534833 | 0.78 | CYP1A2 (0.50) | SMN1; SMN2KMT2ANPC1RAB9ANPSR1 | |
| SCHEMBL9532954 | 0.78 | SMN1; SMN2 (0.41) | SMN1; SMN2KMT2ANPC1RAB9ANPSR1 | |
| SCHEMBL9534961 | 0.78 | CYP1A2 (0.43) | SMN1; SMN2NPC1RAB9ACYP1A2MAPT | |
| SCHEMBL9536137 | 0.76 | DHFR (0.48) | SMN1; SMN2NPC1RAB9ANPSR1L3MBTL1 | |
| SCHEMBL9535141 | 0.71 | CYP1A2 (0.50) | SMN1; SMN2NPC1RAB9ACYP1A2MAPT | |
| SCHEMBL9770762 | 0.71 | CYP1A2 (0.43) | SMN1; SMN2KMT2ARAB9ANPSR1MEN1 | |
| SCHEMBL9534383 | 0.71 | TDP1 (0.50) | SMN1; SMN2L3MBTL1CYP1A2MAPTGAA | |
| SCHEMBL28881648 | 0.71 | CYP1A2 (0.50) | SMN1; SMN2KMT2ANPC1RAB9ANPSR1 | |
| SCHEMBL9534033 | 0.68 | PKM (0.50) | SMN1; SMN2KMT2AL3MBTL1CYP1A2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0263523-B1 | Process for the preparation of thiazolo [2,3-b] quinazolones | BASF AG (DE) | 1993-12-29 | — | — | EP | disclosed |
| EP-0263523-A2 | Process for the preparation of thiazolo [2,3-b] quinazolones | BASF Aktiengesellschaft (DE) | 1988-04-13 | — | — | EP | disclosed |