Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHFR | P00374 | 2/20 | 0.48 |
| ▸ | PKM | P14618 | 4/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | TYMS | P04818 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9534194 | 0.89 | DHFR (0.45) | DHFRPKMCYP1A2TDP1TYMS | |
| SCHEMBL9534961 | 0.83 | CYP1A2 (0.43) | PKMCYP1A2TDP1SMN1; SMN2POLB | |
| SCHEMBL9535141 | 0.79 | CYP1A2 (0.50) | PKMCYP1A2TDP1SMN1; SMN2NPC1 | |
| SCHEMBL9534103 | 0.76 | SMN1; SMN2 (0.41) | DHFRPKMCYP1A2SMN1; SMN2NPC1 | |
| SCHEMBL9534833 | 0.73 | CYP1A2 (0.50) | PKMCYP1A2TDP1SMN1; SMN2NPC1 | |
| SCHEMBL9770762 | 0.73 | CYP1A2 (0.43) | PKMCYP1A2TDP1SMN1; SMN2POLB | |
| SCHEMBL9534383 | 0.73 | TDP1 (0.50) | PKMCYP1A2TDP1SMN1; SMN2POLB | |
| SCHEMBL9534033 | 0.73 | PKM (0.50) | PKMCYP1A2TDP1SMN1; SMN2TSHR | |
| SCHEMBL9534657 | 0.71 | CYP1A2 (0.42) | PKMCYP1A2TDP1SMN1; SMN2NPC1 | |
| SCHEMBL10696638 | 0.70 | CYP1A2 (0.40) | PKMCYP1A2TDP1SMN1; SMN2POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0263523-B1 | Process for the preparation of thiazolo [2,3-b] quinazolones | BASF AG (DE) | 1993-12-29 | — | — | EP | disclosed |
| EP-0263523-A2 | Process for the preparation of thiazolo [2,3-b] quinazolones | BASF Aktiengesellschaft (DE) | 1988-04-13 | — | — | EP | disclosed |