Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | FYN | P06241 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.30 |
| ▸ | CES1 | P23141 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9537248 | 0.87 | KMT2A (0.33) | KMT2A | |
| SCHEMBL11381667 | 0.69 | CYP2A6 (0.36) | LCKFYNDAOKMT2ACES2 | |
| SCHEMBL7813349 | 0.68 | PTPRC (0.49) | LCKFYNDAOKMT2ACES2 | |
| SCHEMBL10518620 | 0.67 | KMT2A (0.39) | KMT2A | |
| SCHEMBL9351950 | 0.64 | GSK3B (0.41) | KMT2A | |
| SCHEMBL3671086 | 0.64 | KMT2A (0.33) | DAOKMT2A | |
| SCHEMBL10587921 | 0.64 | KMT2A (0.37) | DAOKMT2A | |
| SCHEMBL4634541 | 0.63 | KMT2A (0.36) | DAOKMT2A | |
| SCHEMBL4636562 | 0.63 | MAPT (0.40) | KMT2A | |
| SCHEMBL10369277 | 0.63 | KDM4E (0.33) | DAOKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0318682-B1 | TRICYCLIC THIAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1993-03-31 | — | — | EP | disclosed |
| EP-0183994-B1 | TRICYCLIC PYRIDONE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1990-03-21 | — | — | EP | disclosed |
| EP-0318682-A2 | Tricyclic thiazole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1989-06-07 | — | — | EP | disclosed |
| EP-0183994-A1 | Tricyclic pyridone derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1986-06-11 | — | — | EP | disclosed |