Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.30 |
| ▸ | ELANE | P08246 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9534144 | 0.87 | LCK (0.33) | KMT2A | |
| SCHEMBL3672729 | 0.68 | KDM4E (0.37) | KMT2AKDM4E | |
| SCHEMBL10804734 | 0.68 | HPGD (0.41) | KMT2AKDM4E | |
| SCHEMBL8794570 | 0.68 | PTPRC (0.56) | KMT2AKDM4E | |
| SCHEMBL9533816 | 0.66 | KDM4E (0.36) | KMT2AKDM4E | |
| SCHEMBL4607918 | 0.66 | KDM4E (0.36) | KMT2AKDM4E | |
| SCHEMBL9409748 | 0.66 | CUL4A (0.37) | KMT2AKDM4E | |
| SCHEMBL14486887 | 0.66 | MAPT (0.37) | KMT2AKDM4E | |
| SCHEMBL11381667 | 0.66 | CYP2A6 (0.36) | KMT2A | |
| SCHEMBL5240239 | 0.64 | MAPT (0.41) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0318682-B1 | TRICYCLIC THIAZOLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1993-03-31 | — | — | EP | disclosed |
| EP-0318682-A2 | Tricyclic thiazole derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1989-06-07 | — | — | EP | disclosed |
| EP-0183994-A1 | Tricyclic pyridone derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1986-06-11 | — | — | EP | disclosed |