Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 5/20 | 0.58 |
| ▸ | HSD11B1 | P28845 | 7/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ABCC9 | O60706 | 2/20 | 0.37 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.37 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.37 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9294669 | 0.79 | SMN1; SMN2 (0.46) | HTR6HSD11B1KMT2AABCC9ABCC8 | |
| SCHEMBL22954102 | 0.77 | HTR6 (0.61) | HTR6HSD11B1KMT2AABCC9ABCC8 | |
| SCHEMBL6913555 | 0.74 | HTR6 (1.00) | HTR6KMT2AABCC9ABCC8KCNJ11 | |
| SCHEMBL23519060 | 0.72 | HTR6 (0.54) | HTR6HSD11B1KMT2AABCC9ABCC8 | |
| SCHEMBL16649192 | 0.71 | ALDH1A1 (0.40) | HTR6HSD11B1KMT2AHTTTP53 | |
| SCHEMBL11350300 | 0.71 | TDP1 (0.39) | KMT2ATSHRGAA | |
| SCHEMBL30620480 | 0.71 | TSHR (0.38) | KMT2ATSHRTP53 | |
| SCHEMBL18247354 | 0.70 | HTR6 (0.66) | HTR6KMT2ATP53RXFP1 | |
| SCHEMBL4028049 | 0.70 | HTR6 (0.66) | HTR6KMT2ATSHRHTTPOLB | |
| SCHEMBL5366367 | 0.69 | HTR7 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0277612-B1 | SUBSTITUTED 3,4-DIHYDRO-2H-BENZOPYRANES, PROCESS FOR THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL PREPARATIONS BASED ON THESE COMPOUNDS | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-07-28 | — | — | EP | disclosed |
| EP-0277612-A2 | Substituted 3,4-dihydro-2H-benzopyranes, process for their preparation, their use and pharmaceutical preparations based on these compounds | HOECHST AKTIENGESELLSCHAFT (DE) | 1988-08-10 | — | — | EP | disclosed |