Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.45 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | DGKA | P23743 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HTR1A | P08908 | 4/20 | 0.43 |
| ▸ | HTR2C | P28335 | 3/20 | 0.43 |
| ▸ | HRH1 | P35367 | 3/20 | 0.43 |
| ▸ | DRD2 | P14416 | 3/20 | 0.43 |
| ▸ | HTR2A | P28223 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9538894 | 0.89 | SLC6A9 (0.44) | TSHRALDH1A1MAPTHSD17B10CYP2D6 | |
| SCHEMBL8567881 | 0.89 | MAPT (0.44) | TSHRALDH1A1MAPTHSD17B10CYP2D6 | |
| SCHEMBL9536415 | 0.87 | KDM4E (0.48) | TSHRALDH1A1MAPTHSD17B10CYP2D6 | |
| SCHEMBL9536406 | 0.87 | ALDH1A1 (0.37) | TSHRALDH1A1HSD17B10KDM4ETDP1 | |
| SCHEMBL9537922 | 0.83 | ALDH1A1 (0.38) | TSHRALDH1A1MAPTHSD17B10KDM4E | |
| SCHEMBL9537833 | 0.83 | ALDH1A1 (0.39) | TSHRALDH1A1HSD17B10KDM4ECYP2C9 | |
| SCHEMBL9536489 | 0.79 | ADRA1A (0.48) | TSHRALDH1A1MAPTHSD17B10CYP2D6 | |
| SCHEMBL9537953 | 0.78 | KDM4E (0.46) | TSHRALDH1A1MAPTHSD17B10CYP2D6 | |
| SCHEMBL9536136 | 0.77 | SLC6A9 (0.44) | TSHRALDH1A1HSD17B10KDM4ELMNA | |
| Hydrochloric Acid SCHEMBL9535191 | 0.76 | SLC6A9 (0.43) | TSHRALDH1A1HSD17B10KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | claimed |