Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 3/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.46 |
| ▸ | HRH1 | P35367 | 8/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 7/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.45 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.44 |
| ▸ | TRPC7 | Q9HCX4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9537373 | 0.81 | TP53 (0.52) | CYP2C19TP53HRH1CYP2D6SMN1; SMN2 | |
| SCHEMBL10803148 | 0.78 | TP53 (0.47) | CYP2C19CYP2C9CYP1A2TP53HRH1 | |
| SCHEMBL9539548 | 0.78 | KCNH2 (0.61) | CYP2C19CYP2C9CYP1A2TP53HRH1 | |
| SCHEMBL9540017 | 0.75 | PKM (0.54) | TP53HRH1CYP2D6CHRM1SMN1; SMN2 | |
| SCHEMBL9699718 | 0.73 | HRH1 (0.56) | TP53HRH1CYP2D6CHRM1KCNH2 | |
| SCHEMBL9266568 | 0.73 | HRH1 (0.66) | TP53HRH1CYP2D6SMN1; SMN2RAB9A | |
| SCHEMBL9535563 | 0.73 | TP53 (0.51) | TP53HRH1CYP2D6CHRM1SMN1; SMN2 | |
| SCHEMBL15568741 | 0.72 | ALDH1A1 (0.63) | CYP2C19CYP2C9CYP1A2HRH1CYP2D6 | |
| SCHEMBL6995354 | 0.72 | LMNA (0.71) | CYP2C19CYP1A2TP53HRH1CYP2D6 | |
| SCHEMBL477255 | 0.72 | SMN1; SMN2 (0.67) | CYP2C19CYP2C9CYP2D6SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0151826-B1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1993-03-31 | — | — | EP | disclosed |
| US-4839374-A | TREATING ALLERGIES | JANSSEN PHARMACEUTICA, N.V. (BE) | 1989-06-13 | — | — | US | disclosed |
| EP-0151826-A1 | 4-[(Bicyclic heterocyclyl)-methyl and -hetero]-piperidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-08-21 | — | — | EP | disclosed |