Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGM2 | P21980 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | MYC | P01106 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.33 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7603456 | 0.77 | KMT2A (0.40) | POLBKMT2ACYP2D6CYP2C9CYP2C19 | |
| SCHEMBL15157431 | 0.70 | MTNR1A (0.59) | POLBKMT2ACYP2D6CYP2C9CYP2C19 | |
| SCHEMBL30657440 | 0.67 | MTNR1A (0.40) | TGM2POLBKMT2ACYP2D6CYP2C9 | |
| SCHEMBL6407223 | 0.63 | CRHR1 (0.41) | POLBKMT2ACYP2C9KDM4ECYP1A2 | |
| SCHEMBL23300682 | 0.60 | HRH1 (0.36) | POLBKMT2AMYCMTNR1A | |
| SCHEMBL2558541 | 0.58 | MYC (0.36) | KMT2AMYCKDM4EMAPTHSD11B1 | |
| SCHEMBL30081007 | 0.58 | P2RX4 (0.40) | SMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL15156824 | 0.57 | ELANE (0.46) | KMT2AMAPTPTGDR2TP53 | |
| SCHEMBL31267970 | 0.57 | HTR3E (0.40) | HDAC1HDAC6HSD11B1TP53L3MBTL1 | |
| SCHEMBL3585422 | 0.56 | MEN1 (0.61) | KMT2ATP53SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0568540-A1 | 2,4-DIOXO-PYRIDO 2,3-d]PYRIMIDINE-3-ACETIC ACIDS AND ESTERS AND SALTS THEREOF | PFIZER INC. (US) | 1993-11-10 | — | — | EP | disclosed |
| WO-1992012979-A1 | 2,4-DIOXO-PYRIDO [2,3-d]PYRIMIDINE-3-ACETIC ACIDS AND ESTERS AND SALTS THEREOF | PFIZER INC. (US) | 1992-08-06 | — | — | WO | disclosed |