Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PKM | P14618 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.37 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | NLRP3 | Q96P20 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9770496 | 0.82 | CYP1A2 (0.43) | TDP1CYP1A2GAAPKMKDM4E | |
| SCHEMBL9537313 | 0.82 | GAA (0.52) | TDP1CYP1A2GAAPKMLMNA | |
| SCHEMBL9536991 | 0.82 | CYP1A2 (0.50) | TDP1CYP1A2GAAPKMKDM4E | |
| SCHEMBL28345207 | 0.80 | CHEK1 (0.51) | TDP1CYP1A2GAAKDM4EALDH1A1 | |
| SCHEMBL10696259 | 0.79 | CYP1A2 (0.43) | TDP1CYP1A2GAAPKMKDM4E | |
| SCHEMBL9534241 | 0.79 | PKM (0.50) | TDP1CYP1A2PKMKDM4ELMNA | |
| SCHEMBL9534383 | 0.77 | TDP1 (0.50) | TDP1CYP1A2GAAPKMKDM4E | |
| SCHEMBL9534426 | 0.76 | ALDH1A1 (0.43) | TDP1CYP1A2PKMKDM4ELMNA | |
| SCHEMBL6704339 | 0.75 | KDM4E (0.54) | TDP1CYP1A2GAAKDM4ELMNA | |
| SCHEMBL2427361 | 0.70 | CYP1A2 (0.49) | TDP1CYP1A2PKMKDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110862385-B | Application of copper catalyst in preparation of thiazoloquinazolinone derivative through reaction of 1-thiazolylindole compound and tert-butyl nitrite | 苏州大学 | 2020-12-08 | — | — | CN | disclosed |
| CN-110862385-A | Application of copper catalyst in preparation of thiazoloquinazolinone derivative through reaction of 1-thiazolylindole compound and tert-butyl nitrite | 苏州大学 | 2020-03-06 | — | — | CN | disclosed |
| CN-108774248-B | Method for preparing thiazoloquinazolinone derivative | 苏州大学 | 2020-01-14 | — | — | CN | disclosed |
| EP-0263523-B1 | Process for the preparation of thiazolo [2,3-b] quinazolones | BASF AG (DE) | 1993-12-29 | — | — | EP | disclosed |
| EP-0263523-A2 | Process for the preparation of thiazolo [2,3-b] quinazolones | BASF Aktiengesellschaft (DE) | 1988-04-13 | — | — | EP | disclosed |