Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KAT2B | Q92831 | 1/20 | 0.39 |
| ▸ | FLT1 | P17948 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 2/20 | 0.38 |
| ▸ | FLT3 | P36888 | 2/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | TMEM97 | Q5BJF2 | 3/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | PREP | P48147 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9534672 | 0.88 | TMEM97 (0.40) | KAT2BFLT1KDRFLT3KEAP1 | |
| SCHEMBL9533699 | 0.88 | ADRA2A (0.47) | KAT2BFLT1KDRFLT3KEAP1 | |
| SCHEMBL9536218 | 0.81 | L3MBTL1 (0.39) | KEAP1NFE2L2TMEM97SIGMAR1ADORA1 | |
| SCHEMBL9534803 | 0.81 | KAT2B (0.40) | KAT2BFLT1KDRFLT3KEAP1 | |
| SCHEMBL9534051 | 0.75 | ADRA2A (0.51) | SMN1; SMN2 | |
| SCHEMBL9534823 | 0.71 | ADRA2A (0.51) | HTR6ADORA1 | |
| SCHEMBL9534814 | 0.70 | ADRA2A (0.42) | KEAP1NFE2L2TMEM97SIGMAR1ADORA1 | |
| SCHEMBL9534228 | 0.70 | ADRA2A (0.47) | SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9383454 | 0.70 | KDM4E (0.41) | HTR6 | |
| SCHEMBL9379818 | 0.67 | ADRA2A (0.51) | ADORA1SMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0384676-B1 | Alpha-adrenergic receptor antagonists | SMITHKLINE BEECHAM CORP (US) | 1993-11-10 | — | — | EP | disclosed |
| US-4981849-A | OBESITY, DIABETES, CARDIOVASCULAR DISORDERS, DEPRESSION | SMITHKLINE BEECHAM CORPORATION (US) | 1991-01-01 | — | — | US | disclosed |
| EP-0384676-A1 | Alpha-adrenergic receptor antagonists | SMITHKLINE BEECHAM CORPORATION (US) | 1990-08-29 | — | — | EP | disclosed |